ACO1
aconitase 1, soluble
Synonyms:
ACONS, IREB1, IREBP, IREBP1, IRP1
Species:
Human ACO1 (48), Mouse Aco1 (11428), Rat Aco1 (50655), domestic cat ACO1 (101095526), Thale Cress ACO1 (816478), dog ACO1 (481576), sheep ACO1 (101112791), cow ACO1 (512995), Zebrafish aco1 (568448), Thale Cress ACO1 (829737) ...More
UniProtKB ID:
Gene ID:
- Human(48) Summary: The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
- Mouse(11428) aconitase 1
- Rat(50655) aconitase 1, soluble
- domestic cat(101095526) aconitase 1, soluble
- Thale Cress(816478) 1-aminocyclopropane-1-carboxylate oxidase 1
- dog(481576) aconitase 1, soluble
- sheep(101112791) aconitase 1, soluble
- cow(512995) aconitase 1, soluble
- Zebrafish(568448) aconitase 1, soluble
- Thale Cress(829737) aconitate hydratase 1
- Horse(100067866) aconitase 1, soluble
- chicken(373916) aconitase 1, soluble
- naked mole-rat(101716545) aconitase 1, soluble
- domestic guinea pig(100720793) aconitase 1, soluble
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-ACO1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab2,
Species Reactivity
human
Application
immunohistochemistry
Anti-ACO1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-ACO1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, human, pig, rat
Application
immunohistochemistry
western blot
western blot
Anti-Iron Pegulatory Protein 1 Antibody, Chemicon®, from rabbit,
Species Reactivity
rat
Application
ELISA
western blot
western blot
Monoclonal Anti-ACO1 antibody produced in mouse, clone 2C1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot