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  • New possible chelating agents of clinical interest for iron(III): 2-hydroxynicotinic acid and 3-hydroxypicolinic acid. A thermodynamic study.

New possible chelating agents of clinical interest for iron(III): 2-hydroxynicotinic acid and 3-hydroxypicolinic acid. A thermodynamic study.

Annali di chimica (2002-01-05)
V B Di Marco, A Tapparo, G G Bombi
ABSTRACT

The formation of complexes between iron(III) and two ligands of possible relevance to chelation therapy, 2-hydroxynicotinic acid and 3-hydroxypicolinic acid, in aqueous 0.6 m (Na)Cl at 25 degrees C, has been investigated by means of potentiometric titrations and UV measurements. In both cases several mononuclear complexes and their deprotonation products are formed.

MATERIALS
Product Number
Brand
Product Description

Supelco
3-Hydroxypicolinic acid, matrix substance for MALDI-MS, ≥99.0% (HPLC)
Sigma-Aldrich
2-Hydroxypyridine-3-carboxylic acid, 98%
Sigma-Aldrich
3-Hydroxypyridine-2-carboxylic acid, 98%