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  • Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Journal of inorganic biochemistry (2012-07-24)
A G Quiroga
ABSTRACT

This focused review is devoted to our advances in developing trans platinum complexes as antitumoral complexes, in particular those bearing aliphatic amines. It includes some fundamental aspects of the understanding of non conventional metallodrug mechanism. The perspective is arranged by those fundamental aspects and within each section only the most successful examples have been included and also those in which clearly SAR's (structure activity relationships) have been observed.

MATERIALS
Product Number
Brand
Product Description

Platinum, foil, not light tested, 50x50mm, thickness 0.005mm, as rolled, 99.95%
Platinum, foil, not light tested, 50x50mm, thickness 0.004mm, as rolled, 99.95%
Sigma-Aldrich
Platinum, wire, diam. 0.076 mm, ≥99.99% trace metals basis
Sigma-Aldrich
Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis
Sigma-Aldrich
Platinum, foil, thickness 0.25 mm, 99.99% trace metals basis
Sigma-Aldrich
Platinum, foil, thickness 0.1 mm, 99.9% trace metals basis
Sigma-Aldrich
Platinum, foil, thickness 0.127 mm, 99.99% trace metals basis
Sigma-Aldrich
Platinum black, fuel cell grade, ≥99.9% trace metals basis
Sigma-Aldrich
Platinum, gauze, 100 mesh, 99.9% trace metals basis
Sigma-Aldrich
Platinum, wire, diam. 0.127 mm, 99.9% trace metals basis
Sigma-Aldrich
Platinum black, black, powder, ≤20 μm, ≥99.95% trace metals basis
Sigma-Aldrich
Platinum, foil, thickness 0.025 mm, 99.9% trace metals basis
Sigma-Aldrich
Platinum, shot, ≤3 mm, ≥99.9% trace metals basis
Sigma-Aldrich
Platinum, wire, diam. 0.25 mm, 99.9% trace metals basis
Platinum, tube, 100mm, outside diameter 3.0mm, inside diameter 2.8mm, wall thickness 0.1mm, as drawn, 99.95%
Platinum, microfoil, disks, 25mm, thinness 0.1μm, specific density 120μg/cm2, permanent mylar 3.5μm support, 99.99%
Platinum, foil, 25x25mm, thickness 0.25mm, as rolled, 99.99+%
Platinum, rod, 25mm, diameter 1.0mm, 99.95%
Platinum, foil, 30x30mm, thickness 0.2mm, as rolled, 99.95%
Platinum, wire reel, 0.05m, diameter 0.8mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, rod, 10mm, diameter 4.0mm, 99.95%
Platinum, foil, 10mm disks, thickness 0.125mm, as rolled, 99.95%
Platinum, insulated wire, 5m, conductor diameter 0.05mm, insulation thickness 0.009mm, PTFE (polytetrafluoroethylene) insulation, 99.99%
Platinum, tube, 200mm, outside diameter 0.95mm, inside diameter 0.60mm, wall thickness 0.175mm, as drawn, 99.95%
Platinum, wire reel, 0.05m, diameter 1.0mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, foil, 15x15mm, thickness 0.2mm, as rolled, 99.95%
Platinum, wire reel, 0.05m, diameter 1.0mm, as drawn, 99.99+%
Platinum, foil, 8mm disks, thickness 0.004mm, as rolled, 99.95%
Platinum, foil, 10mm disks, thickness 0.125mm, as rolled, 99.99+%
Platinum, wire reel, 0.1m, diameter 0.15mm, annealed, may be used as one component of a thermocouple, 99.99%