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  • A highly enantioselective four-component reaction for the efficient construction of chiral β-hydroxy-α-amino acid derivatives.

A highly enantioselective four-component reaction for the efficient construction of chiral β-hydroxy-α-amino acid derivatives.

Chemical communications (Cambridge, England) (2013-02-26)
Yu Qian, Changcheng Jing, Shunying Liu, Wenhao Hu
ABSTRACT

An enantioselective four-component reaction of a diazoketone, water, an aniline and ethyl glyoxylate in the presence of catalytic Rh2(OAc)4 and a chiral Brønsted acid was developed to efficiently produce β-hydroxy-α-amino acid derivatives in good yields with high diastereoselectivity and enantioselectivity.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Aniline-4-13C, 99 atom % 13C
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Aniline, ACS reagent, ≥99.5%
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Aniline, ReagentPlus®, 99%
Supelco
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Aniline-1-13C, 99 atom % 13C
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Aniline solution, certified reference material, 5000 μg/mL in methanol
Sigma-Aldrich
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