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P3400000

Promethazine hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

10-[2-(Dimethylamino)propyl]phenothiazine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C17H20N2S · HCl
CAS Number:
58-33-3
Molecular Weight:
320.88
Beilstein:
4166397
MDL number:
MFCD00012652
UNSPSC Code:
41116107
PubChem Substance ID:
329820173
NACRES:
NA.24

grade

pharmaceutical primary standard

Agency

EP Reference Standard

API family

promethazine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl[H].CC(CN1c2ccccc2Sc3ccccc13)N(C)C

InChI

1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H

InChI key

XXPDBLUZJRXNNZ-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Promethazine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

Y0000797

Promethazine for peak identification, European Pharmacopoeia (EP) Reference Standard

Y0000769

Promethazine impurity D, European Pharmacopoeia (EP) Reference Standard

1570009

Promethazine hydrochloride, United States Pharmacopeia (USP) Reference Standard

1570029

Promethazine Related Compound B, United States Pharmacopeia (USP) Reference Standard

BP412

Promethazine hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP778

Isopromethazine hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP505

Promethazine sulfoxide, British Pharmacopoeia (BP) Reference Standard

PHR2777

Promethazine Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 50 mg

Signal Word

Danger

Hazard Statements

H302,H317,H318,H411

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Flow injection spectro-electroanalytical method for the determination of promethazine hydrochloride in pharmaceutical preparations.
Daniel D, et al.
Analytica Chimica Acta, 494(1-2), 215-224 (2003)
Mario Schietroma et al.
Journal of the American College of Surgeons, 220(5), 921-933 (2015-04-05)
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. An independent statistical analysis based on the summary data tables and statistical results reported in the
Shigeru Hishinuma et al.
Biochemical pharmacology, 91(2), 231-241 (2014-07-30)
Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and second-generation antihistamines for human
Cheryl C Y Loh et al.
PloS one, 9(10), e110800-e110800 (2014-10-25)
Chloroquine was a cheap, extremely effective drug against Plasmodium falciparum until resistance arose. One approach to reversing resistance is the inhibition of chloroquine efflux from its site of action, the parasite digestive vacuole. Chloroquine accumulation studies have traditionally relied on
Jung Yeon Kim et al.
Biomedical chromatography : BMC, 29(3), 465-474 (2014-08-01)
The purpose of this study was to develop and validate an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistamines (illegal additives) in dietary supplements. The limits of detection and quantitation of the method ranged from 1.5 to 2.5
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