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225282

Sigma-Aldrich

5-Methoxy-1-indanone-3-acetic acid

technical grade

Synonym(s):

6-Methoxy-3-oxo-1-indanacetic acid

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About This Item

Empirical Formula (Hill Notation):
C12H12O4
CAS Number:
24467-92-3
Molecular Weight:
220.22
MDL number:
MFCD00003787
UNSPSC Code:
12352100
PubChem Substance ID:
24853488
NACRES:
NA.22

grade

technical grade

form

powder

mp

139-144 °C (lit.)

solubility

chloroform: soluble 5%, clear, yellow-brown

SMILES string

COc1ccc2C(=O)CC(CC(O)=O)c2c1

InChI

1S/C12H12O4/c1-16-8-2-3-9-10(6-8)7(4-11(9)13)5-12(14)15/h2-3,6-7H,4-5H2,1H3,(H,14,15)

InChI key

QOTZOFGBBCMWEP-UHFFFAOYSA-N

General description

The 5-methoxy-1-indanone-3-acetic acid derivatives are potent inhibitors of chymotrypsin-like activity of the 20S proteasome.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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R T Lum et al.
Bioorganic & medicinal chemistry letters, 8(3), 209-214 (1999-01-01)
Potent inhibitors of the 20S proteasome that contain a novel indanone head group coupled to di and tripeptides are described. These compounds are the first proteasome inhibitors have demonstrated high selectivity for the chymotrypsin-like activity of the 20S proteasome.

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