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GC Injection Port Issues: Two Case Studies (Peak Tailing and Low Response)

Proper product selection and preventative maintenance for the GC inlet are vital elements that impact performance of the GC instrument.

Mild Mg – Halogen Exchange

Substantial progress has been made in magnesium–halogen exchange reactions used for the preparation of functionalized Grignard reagents containing sensitive moieties such as ester or cyano groups.

Measuring Flows For Gas Chromatography Volumetric vs. Mass

Resolving by Mass

Hopane Reference Standards for use as Petrochemical Biomarkers in Oil Field Remediation and Spill Analysis

We provide high-quality, relevant hopane reference standards to be used as biomarkers for petrochemical oil field remediation and spill analysis.

G3 and G4 Buchwald Precatalysts

G3 and G4 Buchwald palladium precatalysts are the newest air, moisture, and thermally stable crossing-coupling complexes used in bond formation for their versatility and high reactivity.

NIOSH 9000

For NIOSH 9000this page lists applicable products and materials to do the application

Organic Azides and Azide Sources

Since the preparation of the first organic azide, phenyl azide, by Peter Griess in 1864 this energy-rich and versatile class of compounds has enjoyed considerable interest.

Passive (Diffusive) Sampling Overview

For faster sampling rates, shorter sampling times, greater sensitivity and higher capacity allowing longer sampling times, discover our range of radial devices.

ECACC Nucleic Acids

DNA, RNA, cDNA derived from ECACC mammalian cell lines allow screening for genes or expression patterns to identify lines most suitable for specific research.

Palau’Chlor®: Easily and Selectively Functionalize Lead Compounds

Aryl chlorides are commonly used in cross-coupling reactions and can serve as key intermediates towards the synthesis of pharmaceutical drug candidates and natural products.

Primary Human Preadipocytes and Preadipocyte/Adipocyte Growth & Differentiation Media

Primary human white preadipocytes and culture media for the expansion of undifferentiated preadipocytes, differentiation to adipocytes, and cultivation of mature adipocytes. Protocols for handling, cell passaging, media, and product use.

ThermaStop™ PCR Additive

PCR additive added to master mix that stops nonspecific bands after cool down.

Ascentis® Express C8 U/HPLC Columns

When a C18 doesn′t give the desired separation, or your sample contains compounds that are known to be difficult to retain or resolve on a C18, consider changing to an Ascentis® Express C8 column.

Trichloroacetimidate Reagents

Trichloroacetimidates are also commonly employed as alcohol alkylation reagents, particularly when existing functionality is not acid sensitive.

1-hydrosilatrane

As a versatile hydride reagent, 1-hydrosilatrane can be used in reduction reactions to synthesize alcohols, amines, their chiral counterparts, and esters from aldehydes/ketones.

HPLC Analysis of Protein Standards (1) on BIOshell™ A400 Protein C4

For use as a marker in SDS-PAGE; Albumin from chicken egg white, For use as a marker in SDS-PAGE; L-Lactic Dehydrogenase from rabbit muscle, Type XI, lyophilized powder, 600-1,200 units/mg protein

HPLC Columns for Antibody and Large Protein Analysis

BIOshell™ IgG 1000 Å C4 columns are highly suited for the reversed phase separation of high molecular weight compounds such as monoclonal antibodies with molecular weight of 150 kDa.

Hematopoietic Cytokines

Read article on hematopoietic cytokines and hematopoiesis

MCAT- 53™ Catalyst for Ruthenium Formation

A recyclable, ligand-free ruthenium catalyst for C–H activation reactions and concomitant C–C bond formation in the presence of water.

McCoy's 5A Modified Media Formulation

Protected Carbohydrate Building Blocks for More Efficient Syntheses

Carbohydrates and their biologically active glycoconjugate analogs are emerging as an important class of biomolecules.

Williams' Medium E Formulation

Ring-Closing Alkyne Metathesis (RCAM)

Alkyne metathesis has been a useful tool for C–C bond formation since the discovery of structurally well-defined metal alkylidynes by Schrock and coworkers.

General Adherent Cells

Protocol for creating create stable cell lines from both dividing and non-dividing cells for use with a lentiviral delivery system.

Pooled Lentiviral shRNA Screens to Identify Essential Cancer Pathways

Presenting an article on Pooled Lentiviral shRNA Screens to Identify Essential Cancer Pathways

CRISPR-based Gene Activation

Sigma has developed a gene activation system based on a fusion of dCas9 to the catalytic histone acetyltransferase (HAT) core domain of the human E1A-associated protein p300.

Introduction to DNA Methylation

Epigenetic regulation starts with DNA wound around a set of completely acetylated histones associated with an activated, fully transcribed gene.

Analysis of Fluorescent Dyes Used for Labeling DNA in Microarray Experiments

An article concerning Analyzing Properties of Fluorescent Dyes for Labeling DNA in Microarray Experiments presented by Sigma-Aldrich.com

Discovery and Single Crystal Growth of Lanthanide Intermetallics—Interplay of Synthesis and Physical Properties

Solid state and materials chemistry have made a tremendous impact and have experienced growth in recent years, particularly for rare earthcontaining materials.

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