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  • Use of the loop diuretic torsemide in three dogs with advanced heart failure.

Use of the loop diuretic torsemide in three dogs with advanced heart failure.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology (2011-10-28)
Mark A Oyama, Gordon D Peddle, Caryn A Reynolds, Gretchen E Singletary
ABSTRACT

Diuretics are a mainstay of therapy in dogs with heart failure. In dogs with advanced heart failure, moderate to high doses of loop diuretics such as furosemide are used with diminishing effects as profound activation of neuroendocrine systems promote signs of congestive heart failure. The loop diuretic torsemide has several characteristics that make it suitable for treatment of advanced heart failure including longer half-life, increased potency of diuretic action, and anti-aldosterone effects. This case report details the administration of torsemide in 3 dogs with advanced heart failure and apparent furosemide resistance.

MATERIALS
Product Number
Brand
Product Description

Torasemide for system suitability, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Torsemide, ≥98% (HPLC), solid
Torasemide anhydrous, European Pharmacopoeia (EP) Reference Standard