- Expedient preparation of all isomers of 2-aminocyclobutanecarboxylic acid in enantiomerically pure form.
Expedient preparation of all isomers of 2-aminocyclobutanecarboxylic acid in enantiomerically pure form.
The Journal of organic chemistry (2009-03-17)
Carlos Fernandes, Elisabeth Pereira, Sophie Faure, David J Aitken
PMID19284796
ABSTRACT
A short, convenient, gram scale protocol has been established to allow facile access to all four stereoisomers of 2-aminocyclobutanecarboxylic acid, each in enantiomerically pure form (ee >99%). Starting from the readily available cis racemate, the procedure combines efficient alpha-phenylethylamine derivative resolution and controlled cis-to-trans epimerization procedures, and proceeds with invariably high yields.
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