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Merck

THRB

thyroid hormone receptor, beta

Synonyms:
C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2
Species:
UniProtKB ID:
Gene ID:
  • Human(7068) Summary: The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(21834) thyroid hormone receptor beta
  • Rat(24831) thyroid hormone receptor beta
  • Domestic Rabbit(100303763) thyroid hormone receptor, beta
  • chicken(396431) thyroid hormone receptor, beta
  • cow(788329) thyroid hormone receptor, beta
  • domestic cat(101084821) thyroid hormone receptor, beta
  • Horse(100051615) thyroid hormone receptor, beta
  • dog(403599) thyroid hormone receptor, beta
  • naked mole-rat(101719651) thyroid hormone receptor, beta
  • domestic guinea pig(100721125) thyroid hormone receptor, beta
  • Zebrafish(30607) thyroid hormone receptor beta

Custom & Knockdown Gene Products

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  • Custom Gene Products

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Small Molecule - Agonist

Product Number
Description
Species
Liothyronine sodium, European Pharmacopoeia (EP) Reference Standard,
Species
human
3,3′,5-Triiodo-L-thyronine (T3) solution, 100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
L-Thyroxine (T4) solution, 100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Levothyroxine sodium, European Pharmacopoeia (EP) Reference Standard,
Species
human
Liothyronine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
3,3′,5-Triiodo-L-thyronine, ≥95% (HPLC), powder,
Species
rat, human
3,3′,5-Triiodo-L-thyronine sodium salt, powder, BioReagent, suitable for cell culture,
Species
rat, human
3,3′,5-Triiodo-L-thyronine sodium salt, γ-irradiated, powder, suitable for, suitable for cell culture,
Species
rat, human
3,3′,5-Triiodothyroacetic acid, ≥90%,
Species
rat, human
L-Thyroxine, ≥98% (HPLC),
Species
human, mouse, rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-phospho-TR-β1 (pSer142) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-Thyroid Hormone Receptor β, N-Terminal antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Anti-THRB antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human, mouse, rat
Application
ELISA
western blot
Anti-THRB antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence

Small Molecule - Blocker

Product Number
Description
Species
3,3′,5-Triiodo-L-thyronine, ≥95% (HPLC), powder,
Species
rat, human
3,3′,5-Triiodo-L-thyronine sodium salt, powder, BioReagent, suitable for cell culture,
Species
rat, human
3,3′,5-Triiodo-L-thyronine sodium salt, γ-irradiated, powder, suitable for, suitable for cell culture,
Species
rat, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human THRB,
Species
human