SUN2
Sad1 and UNC84 domain containing 2
Synonyms:
UNC84B
Species:
Human SUN2 (25777), Mouse Sun2 (223697), Rat Sun2 (315135), dog SUN2 (481250), domestic cat SUN2 (101096079), chicken SUN2 (418021), naked mole-rat Sun2 (101703115), Thale Cress SUN2 (820242), domestic guinea pig Sun2 (100734538), sheep SUN2 (101106156)
UniProtKB ID:
Gene ID:
- Human(25777) Summary: SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]
- Mouse(223697) Sad1 and UNC84 domain containing 2
- Rat(315135) Sad1 and UNC84 domain containing 2
- dog(481250) Sad1 and UNC84 domain containing 2
- domestic cat(101096079) Sad1 and UNC84 domain containing 2
- chicken(418021) Sad1 and UNC84 domain containing 2
- naked mole-rat(101703115) Sad1 and UNC84 domain containing 2
- Thale Cress(820242) SAD1/UNC-84 domain-containing protein 2
- domestic guinea pig(100734538) Sad1 and UNC84 domain containing 2
- sheep(101106156) Sad1 and UNC84 domain containing 2
- cow(618392) Sad1 and UNC84 domain containing 2
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