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Merck

SAFB

scaffold attachment factor B

Synonyms:
HAP, HET, SAF-B1, SAFB1
Species:
Human SAFB (6294), Mouse Safb (224903), Rat Safb (64196), chicken SAFB (426047), Zebrafish safb (321979), domestic guinea pig Safb (100718986), naked mole-rat Safb (101713322), domestic cat SAFB (101092244), cow SAFB (539785), dog SAFB (485028)
UniProtKB ID:
Q15424, A0AV56, B7Z5B6, B7ZLP6, F5H0H3, O60406, Q59HH8
Gene ID:
  • Human(6294) Summary: This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]
  • Mouse(224903) scaffold attachment factor B
  • Rat(64196) scaffold attachment factor B
  • chicken(426047) scaffold attachment factor B
  • Zebrafish(321979) scaffold attachment factor B
  • domestic guinea pig(100718986) scaffold attachment factor B
  • naked mole-rat(101713322) scaffold attachment factor B
  • domestic cat(101092244) scaffold attachment factor B
  • cow(539785) scaffold attachment factor B
  • dog(485028) scaffold attachment factor B

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB2702149
Monoclonal Anti-SAFB antibody produced in mouse, ,
Species Reactivity
human, mouse
Application
immunocytochemistry
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
ZRB2171
Anti-SAFB Antibody, clone 2N15-L2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse
Application
immunocytochemistry
immunohistochemistry
western blot
HPA016832
Anti-SAFB antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
HPA020076
Anti-SAFB antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
05-588
Anti-HET/SAF-B Antibody, clone 6F7, clone 6F7, Upstate®, from mouse,
Species Reactivity
human
Application
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot

esiRNA

Product Number
Description
Species
EHU009431
MISSION® esiRNA, targeting human SAFB,
Species
human
EMU167381
MISSION® esiRNA, targeting mouse Safb,
Species
mouse