ATP6V0A4
ATPase, H+ transporting, lysosomal V0 subunit a4
Synonyms:
A4, ATP6N1B, ATP6N2, RDRTA2, RTA1C, RTADR, STV1, VPH1, VPP2
Species:
Human ATP6V0A4 (50617), Mouse Atp6v0a4 (140494), Rat Atp6v0a4 (296981), sheep ATP6V0A4 (101104057), cow ATP6V0A4 (518974), dog ATP6V0A4 (482779), domestic cat ATP6V0A4 (101089593), domestic guinea pig Atp6v0a4 (100735854), Horse ATP6V0A4 (100064797), Domestic Rabbit ATP6V0A4 (100347541) ...More
UniProtKB ID:
Gene ID:
- Human(50617) Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing. [provided by RefSeq, Jul 2008]
- Mouse(140494) ATPase, H+ transporting, lysosomal V0 subunit A4
- Rat(296981) ATPase, H+ transporting, lysosomal V0 subunit A4
- sheep(101104057) ATPase, H+ transporting, lysosomal V0 subunit a4
- cow(518974) ATPase, H+ transporting, lysosomal V0 subunit a4
- dog(482779) ATPase, H+ transporting, lysosomal V0 subunit a4
- domestic cat(101089593) ATPase, H+ transporting, lysosomal V0 subunit a4
- domestic guinea pig(100735854) ATPase, H+ transporting, lysosomal V0 subunit a4
- Horse(100064797) ATPase, H+ transporting, lysosomal V0 subunit a4
- Domestic Rabbit(100347541) ATPase, H+ transporting, lysosomal V0 subunit a4
- chicken(418104) ATPase, H+ transporting, lysosomal V0 subunit a4
- naked mole-rat(101719254) ATPase, H+ transporting, lysosomal V0 subunit a4
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-ATP6V0A4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry