ALS2
amyotrophic lateral sclerosis 2 (juvenile)
Synonyms:
ALS2CR6, ALSJ, IAHSP, PLSJ
Species:
Human ALS2 (57679), Mouse Als2 (74018), Rat Als2 (363235), naked mole-rat Als2 (101698373), cow ALS2 (535750), Domestic Rabbit ALS2 (100345931), sheep ALS2 (101109592), domestic cat ALS2 (101094869), dog ALS2 (478872), domestic guinea pig Als2 (100717157)
UniProtKB ID:
Gene ID:
- Human(57679) Summary: The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
- Mouse(74018) amyotrophic lateral sclerosis 2 (juvenile)
- Rat(363235) amyotrophic lateral sclerosis 2 (juvenile)
- naked mole-rat(101698373) amyotrophic lateral sclerosis 2 (juvenile)
- cow(535750) amyotrophic lateral sclerosis 2 (juvenile)
- Domestic Rabbit(100345931) amyotrophic lateral sclerosis 2 (juvenile)
- sheep(101109592) amyotrophic lateral sclerosis 2 (juvenile)
- domestic cat(101094869) amyotrophic lateral sclerosis 2 (juvenile)
- dog(478872) amyotrophic lateral sclerosis 2 (juvenile)
- domestic guinea pig(100717157) amyotrophic lateral sclerosis 2 (juvenile)
- chicken(424085) amyotrophic lateral sclerosis 2 (juvenile)
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-ALS2 antibody produced in mouse, clone 4F9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-ALS2 (C-terminal) antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
immunohistochemistry
Anti-ALS2 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-Als2 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
Anti-ALS2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry