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Metabolism of glucurolactone to glucarate in Parkinson's disease.

Neurology (1992-09-01)
W C Koller, S D Rope, S J Huber, D C Blumenthal, H J Blumenthal
ABSTRACT

The metabolism of oral glucurolactone to serum D-glucarate by the hepatic cytochrome P450 enzyme system was no different in 20 untreated Parkinson's disease (PD) patients as compared with 20 age- and sex-matched controls. There was no evidence for a deficit in hepatic enzymes in PD.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
D-(+)-Glucuronic acid γ-lactone, ≥99%