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  • CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology.

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology.

Nature neuroscience (2013-05-28)
Elizabeth M Bradshaw, Lori B Chibnik, Brendan T Keenan, Linda Ottoboni, Towfique Raj, Anna Tang, Laura L Rosenkrantz, Selina Imboywa, Michelle Lee, Alina Von Korff, Martha C Morris, Denis A Evans, Keith Johnson, Reisa A Sperling, Julie A Schneider, David A Bennett, Philip L De Jager
PMID23708142
ABSTRACT

In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444(C) risk allele was associated with greater cell surface expression of CD33 in the monocytes (t50 = 10.06, P(joint) = 1.3 × 10(-13)) of young and older individuals. It was also associated with diminished internalization of amyloid-β 42 peptide, accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging, and increased numbers of activated human microglia.

MATERIALS
Product Number
Brand
Product Description
09184
Sigma-Aldrich
Dextran from Leuconostoc spp., Mr ~100,000
00895
Supelco
Dextran, analytical standard, for GPC, 410,000
31430
Supelco
Dextran, analytical standard, for GPC, Set Mp 1,000-400,000
31419
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 25,000
31425
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 670,000
31424
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Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 410,000
31416
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 1,000
31398
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Dextran from Leuconostoc mesenteroides, Mr ~200,000
00896
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Dextran, analytical standard, for GPC, 670,000
00894
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Dextran, analytical standard, for GPC, 270,000
31387
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Dextran from Leuconostoc spp., Mr 15,000-25,000
D4876
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Dextran from Leuconostoc mesenteroides, average mol wt 150,000
D5376
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Dextran from Leuconostoc mesenteroides, average mol wt 1,500,000-2,800,000
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Dextran from Leuconostoc mesenteroides, average mol wt 48,000-90,000
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Dextran from Leuconostoc mesenteroides, average mol wt 9,000-11,000
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Dextran from Leuconostoc spp., Mr 450,000-650,000
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Dextran from Leuconostoc spp., Mr ~70,000
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Dextran, enzymatic synth.
31388
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Dextran from Leuconostoc spp., Mr ~6,000
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Dextran from Leuconostoc mesenteroides, Mr ~60,000
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Dextran from Leuconostoc spp., Mr ~40,000
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Dextran from Leuconostoc mesenteroides, average mol wt 15,000-30,000
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Dextran from Leuconostoc mesenteroides, average mol wt 35,000-45,000
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Dextran from Leuconostoc mesenteroides, average mol wt 60,000-76,000
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Dextran, analytical standard, for GPC, 5,000
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Dextran, analytical standard, for GPC, 150,000
00270
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Dextran, analytical standard, for GPC, 12,000
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Dextran, analytical standard, for GPC, 50,000
00892
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Dextran, analytical standard, for GPC, 80,000
31420
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Dextran from Leuconostoc mesenteroides, for GPC, analytical standard, Mw 50,000