- Kinetic resolutions of indan derivatives using bacteria.
Kinetic resolutions of indan derivatives using bacteria.
Bioscience, biotechnology, and biochemistry (2002-05-10)
Naoki Tarui, Hayao Watanabe, Kohji Fukatsu, Shigenori Ohkawa, Kazuo Nakahama
PMID11999429
ABSTRACT
Racemic indan derivatives have been resolved by the hydrolysis of amide bonds using Corynebacterium ammoniagenes IFO12612 to produce (S)-amine and (R)-amides. In the kinetic resolution of 1 (N-12-(6-methoxy-indan-1-yl)ethyl]acetamide), it was possible to run the reaction to 44% conversion on a 10-g scale, obtaining (S)-amine 4 ((S)-2-(6-methoxy-indan-1-yl)ethylamine) at >99% enantiomeric excess (ee) and (R)-1 at 98% ee.