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Key Documents

81172

Sigma-Aldrich

Poly(ethylene glycol)

tested according to Ph. Eur., 400

Synonym(s):

Macrogol 400, Polyethylene glycol, PEG

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About This Item

Linear Formula:
H(OCH2CH2)nOH
CAS Number:
MDL number:
UNSPSC Code:
12352104
PubChem Substance ID:
NACRES:
NA.21

Agency

tested according to Ph. Eur.

Quality Level

form

liquid

mol wt

380-420

application(s)

pharmaceutical (small molecule)

SMILES string

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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General description

Polyethylene glycol (PEG) is a polyether compound with repeated ethylene glycol units[-(CH2CH2O)n].

Application

Poly(ethylene glycol) has been used as a liquid medium to prepare shear thickening fluid (STF) by directly mixing it with fumica silica.

Biochem/physiol Actions

Polyethylene glycol (PEG) is a synthetic polymer and is used as an additive in food, cosmetics, and pharmaceuticals. It is also involved in biomedical applications like biosensing, imaging, and tissue engineering. PEG is used as a gold standard in bioconjugation and nanomedicine thereby increasing blood circulation time and improving drug efficacy. PEG-conjugated drugs are approved by the U.S. Food and Drug Administration (FDA). They are considered safe for use in humans. PEG reduces the liver uptake and repels protein adsorption, which makes it useful in nanocoating.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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The stab resistance of fabrics impregnated with shear thickening fluids including various particle size of additives
Gurgen S and Kucshan MC
Composites Part A: Applied Science and Manufacturing, 94, 50-60 (2017)
The rheology of shear thickening fluids with various ceramic particle additives
Gurgen S, et al.
Materials & Design, 104, 312-319 (2016)
The ballistic performance of aramid based fabrics impregnated with multi-phase shear thickening fluids
Gurgen S and Kucshan MC
Polymer Testing, 64, 296-306 (2017)
Thai Thanh Hoang Thi et al.
Polymers, 12(2) (2020-02-07)
Poly(ethylene glycol) (PEG) is widely used as a gold standard in bioconjugation and nanomedicine to prolong blood circulation time and improve drug efficacy. The conjugation of PEG to proteins, peptides, oligonucleotides (DNA, small interfering RNA (siRNA), microRNA (miRNA)) and nanoparticles
Janina-Miriam Noy et al.
Biomacromolecules, 21(6), 2320-2333 (2020-04-29)
Phosphorylcholine is known to repel the absorption of proteins onto surfaces, which can prevent the formation of a protein corona on the surface of nanoparticles. This can influence the fate of nanoparticles used for drug delivery. This material could therefore

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