49510

L-Glutamic acid γ-benzyl ester

≥99.0% (T)

• Synonym(s): L-Glutamic acid 5-benzyl ester
• Linear Formula: C₆H₅CH₂OCOCH₂CH₂CH(NH₂)COOH
• CAS Number: 1676-73-9
• Molecular Weight: 237.25
• Beilstein: 1885646
• EC Number: 216-826-1
• MDL number: MFCD00002633
• UNSPSC Code: 12352209
• PubChem Substance ID: 57651200
• NACRES: NA.22

Properties

• Assay: ≥99.0% (T)
• optical activity: [α]20/D +19±2°, c = 1% in acetic acid
• reaction suitability: reaction type: solution phase peptide synthesis
• mp: 181-182 °C (lit.)
• application(s): peptide synthesis
• storage temp.: 2-8°C
• SMILES string: N[C@@H](CCC(=O)OCc1ccccc1)C(O)=O
• InChI: 1S/C12H15NO4/c13-10(12(15)16)6-7-11(14)17-8-9-4-2-1-3-5-9/h1-5,10H,6-8,13H2,(H,15,16)/t10-/m0/s1
• InChI key: BGGHCRNCRWQABU-JTQLQIEISA-N

Description

Application

L-Glutamic acid γ-benzyl ester is commonly used in the synthesis of polymers for biological applications. Some of the examples are:

• Synthesis of bioreducible block copolymers based on poly(ethylene glycol) and poly(γ-benzyl L-glutamate) for Intracellular drug delivery.
• Synthesis of biodegradable poly(L-glutamic acid)-b-polylactide for magnetic resonance imaging (MRI)-visible drug delivery system.
• Synthesis of pH and temperature-responsive diblock copolymers based on poly(L-glutamic acid).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves