Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.

Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.

Organic letters (2005-05-07)

Benedek Vakulya, Szilárd Varga, Antal Csámpai, Tibor Soós

RÉSUMÉ

Cinchona alkaloid-derived chiral bifunctional thiourea organocatalysts were synthesized and applied in the Michael addition between nitromethane and chalcones with high ee and chemical yields.

MATÉRIAUX

Référence du produit

Marque

Description du produit

360554

Sigma-Aldrich

Nitromethane, ACS reagent, ≥95%

230731

Sigma-Aldrich

Nitromethane, ReagentPlus^®, ≥99.0%

270423

Sigma-Aldrich

Nitromethane, suitable for HPLC, ≥96%

690481

Sigma-Aldrich

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8a,9S)-6′-methoxy-9-cinchonanyl]thiourea, 90%

690384

Sigma-Aldrich

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8a,9S)-10,11-dihydro-6′-methoxy-9-cinchonanyl]thiourea, 90%