- Gastro retention using polymer cocoons.
Gastro retention using polymer cocoons.
Artificial cells, nanomedicine, and biotechnology (2014-08-01)
Julien Arnold, David Hunkeler
PMID25078789
RÉSUMÉ
A gastro-retentive capsule has been prepared which is retained in the stomach for a period of 24h, providing a vehicle for the controlled delivery to the upper intestines. These "gastro cocoons" can resist passage through the sphincter of the stomach, and can retain a high drug payload (30%). They are made from oppositely charged polyelectrolytes and can swell to twice their initial volume. They are strong and also can resist 550 N of compressive force. They are based on filled pharmaceutical capsules which are visible to X-rays. Using ambroxol hydrochloride as a model drug linear, zero-order, release curves were obtained.
MATÉRIAUX
Référence du produit
Marque
Description du produit
Sigma-Aldrich
Acide chlorhydrique, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., fuming, ≥37%, APHA: ≤10
Sigma-Aldrich
Acide chlorhydrique, meets analytical specification of Ph. Eur., BP, NF, fuming, 36.5-38%