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Merck

Chemical modification of neamine.

Carbohydrate research (1977-02-01)
T Suami, S Nishiyama, Y Ishikawa, S Katsura
PMID404040
RÉSUMÉ

The aminocyclitol antibiotic neamine has been modified chemically by removing one or two hydroxyl groups from the 2-deoxystreptamine moiety to give 5- and 6- deoxyneamines (5 and 10), as well as 5,6-dideoxyneamine (15). Their antimicrobial activities were determined against several microorganisms, including kanamycin-resistant strains.

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