Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Journal of inorganic biochemistry (2012-07-24)

A G Quiroga

PMID22819649

RÉSUMÉ

This focused review is devoted to our advances in developing trans platinum complexes as antitumoral complexes, in particular those bearing aliphatic amines. It includes some fundamental aspects of the understanding of non conventional metallodrug mechanism. The perspective is arranged by those fundamental aspects and within each section only the most successful examples have been included and also those in which clearly SAR's (structure activity relationships) have been observed.

MATÉRIAUX

Référence du produit

Marque

Description du produit

298093

Sigma-Aldrich

Platinum, gauze, 100 mesh, 99.9% trace metals basis

205915

Sigma-Aldrich

Platinum black, black, powder, ≤20 μm, ≥99.95% trace metals basis

327492

Sigma-Aldrich

Platinum, wire, diam. 1.0 mm, 99.9% trace metals basis

267201

Sigma-Aldrich

Platinum, wire, diam. 0.5 mm, 99.99% trace metals basis

267244

Sigma-Aldrich

Platinum, foil, thickness 0.025 mm, 99.9% trace metals basis

204013

Sigma-Aldrich

Platinum, powder, 99.995% trace metals basis

349402

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.9% trace metals basis

267228

Sigma-Aldrich

Platinum, wire, diam. 0.5 mm, 99.9% trace metals basis

298107

Sigma-Aldrich

Platinum, gauze, 52 mesh, 99.9% trace metals basis

685453

Sigma-Aldrich

Platinum, nanopowder, <50 nm particle size (TEM)

520780

Sigma-Aldrich

Platinum black, fuel cell grade, ≥99.9% trace metals basis

349356

Sigma-Aldrich

Platinum, foil, thickness 0.05 mm, 99.99% trace metals basis

444685

Sigma-Aldrich

Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis

357367

Sigma-Aldrich

Platinum, wire, diam. 0.10 mm, 99.99% trace metals basis

GF49364264

Platinum, wire reel, 1m, diameter 0.5mm, as drawn, 99.99+%

520799

Sigma-Aldrich

Platinum black, low bulk density, ≥99.9% trace metals basis

267171

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.99% trace metals basis

771937

Sigma-Aldrich

Platinum, nanopowder, 200 nm particle size (SEM), 99.9% (metals basis)

GF98759200

Platinum, foil, not light tested, 100x100mm, thickness 0.0125mm, as rolled, 99.95%

349321

Sigma-Aldrich

Platinum, foil, thickness 0.25 mm, 99.99% trace metals basis

373265

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, thermocouple grade

349372

Sigma-Aldrich

Platinum, foil, thickness 1.0 mm, 99.99% trace metals basis

GF80394914

Platinum, wire reel, 0.5m, diameter 0.5mm, as drawn, 99.99+%

267163

Sigma-Aldrich

Platinum, wire, diam. 0.127 mm, 99.99% trace metals basis

GF21250594

Platinum, tube, 100mm, outside diameter 0.95mm, inside diameter 0.60mm, wall thickness 0.175mm, as drawn, 99.95%

204048

Sigma-Aldrich

Platinum, powder (coarse), 99.99% trace metals basis

GF22473941

Platinum, wire reel, 10m, diameter 0.025mm, hard, 99.9%

GF60279576

Platinum, foil, 25x25mm, thickness 0.25mm, as rolled, 99.95%

GF02251730

Platinum, rod, 200mm, diameter 1.0mm, 99.95%

GF90182257

Platinum, foil, 25x25mm, thickness 0.1mm, as rolled, 99.99+%