- Synthesis of the key precursor of Hirsutellide A.
Synthesis of the key precursor of Hirsutellide A.
Molecules (Basel, Switzerland) (2007-11-17)
Yanjie Xu, Xuemin Duan, Meiling Li, Liqin Jiang, Guangle Zhao, Yi Meng, Ligong Chen
PMID18007294
RÉSUMÉ
Hexadepsipeptide 2, the precursor of Hirsutellide A (1), was synthesized in an overall yield of 45% from N-Boc-Me-Gly via three coupling reactions using dicyclohexylcarbodiimide (DCC), O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyl- uronium hexafluorophosphate (HATU) and bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl), respectively.
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