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Merck

Honokiol: a novel natural agent for cancer prevention and therapy.

Current molecular medicine (2012-07-28)
S Arora, S Singh, G A Piazza, C M Contreras, J Panyam, A P Singh
RÉSUMÉ

Honokiol (3',5-di-(2-propenyl)-1,1'-biphenyl-2,4'-diol) is a bioactive natural product derived from Magnolia spp. Recent studies have demonstrated anti-inflammatory, anti-angiogenic, anti-oxidative and anticancer properties of honokiol in vitro and in preclinical models. Honokiol targets multiple signaling pathways including nuclear factor kappa B (NF-κB), signal transducers and activator of transcription 3 (STAT3), epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (m-TOR), which have great relevance during cancer initiation and progression. Furthermore, pharmacokinetic profile of honokiol has revealed a desirable spectrum of bioavailability after intravenous administration in animal models, thus making it a suitable agent for clinical trials. In this review, we discuss recent data describing the molecular targets of honokiol and its anti-cancer activities against various malignancies in pre-clinical models. Evaluation of honokiol in clinical trials will be the next step towards its possible human applications.

MATÉRIAUX
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Description du produit

Sigma-Aldrich
Honokiol, ≥98% (HPLC), powder
Supelco
Honokiol, analytical standard
Honokiol, European Pharmacopoeia (EP) Reference Standard