Preparation of (Cyanomethylene)tributylphosphorane: a new mitsunobu-type reagent.

Preparation of (Cyanomethylene)tributylphosphorane: a new mitsunobu-type reagent.

Chemical & pharmaceutical bulletin (2005-11-08)

Izumi Sakamoto, Takeshi Nishii, Fumie Ozaki, Hiroto Kaku, Masami Tanaka, Tetsuto Tsunoda

RÉSUMÉ

(Cyanomethylene)tributylphosphorane (CMBP), which promoted the alkylation of various nucleophiles (HA) with alcohols (ROH) to give RA (Mitsunobu-type reaction), was prepared in two steps starting from chloroacetonitrile.

MATÉRIAUX

Référence du produit

Marque

Description du produit

752959

Sigma-Aldrich

(Tributylphosphoranylidene)acetonitrile solution, 1 M in toluene

C19651

Sigma-Aldrich

Chloroacetonitrile, 99%