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Merck

Wireless Non-Invasive Monitoring of Cholesterol Using a Smart Contact Lens.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2022-08-18)
Hayoung Song, Haein Shin, Hunkyu Seo, Wonjung Park, Byung Jun Joo, Jeongho Kim, Jeonghyun Kim, Hong Kyun Kim, Jayoung Kim, Jang-Ung Park
RÉSUMÉ

Herein, a wireless and soft smart contact lens that enables real-time quantitative recording of cholesterol in tear fluids for the monitoring of patients with hyperlipidemia using a smartphone is reported. This contact lens incorporates an electrochemical biosensor for the continuous detection of cholesterol concentrations, stretchable antenna, and integrated circuits for wireless communication, which makes a smartphone the only device required to operate this lens remotely without obstructing the wearer's vision. The hyperlipidemia rabbit model is utilized to confirm the correlation between cholesterol levels in tear fluid and blood and to confirm the feasibility of this smart contact lens for diagnostic application of cholesterol-related diseases. Further in vivo tests with human subjects demonstrated its good biocompatibility, wearability, and reliability as a non-invasive healthcare device.

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Description du produit

Sigma-Aldrich
Cholesterol Oxidase from Streptomyces sp., lyophilized powder, ≥20 units/mg protein