- Palladium-Catalyzed C-O Cross-Coupling of Primary Alcohols.
Palladium-Catalyzed C-O Cross-Coupling of Primary Alcohols.
Organic letters (2018-02-24)
Hong Zhang, Paula Ruiz-Castillo, Stephen L Buchwald
PMID29474078
RÉSUMÉ
Two catalyst systems are described, which together provide mild and general conditions for the Pd-catalyzed C-O cross-coupling of primary alcohols. For activated substrates, such as electron-deficient aryl halides, the commercially available ligand L2 promotes efficient coupling for a variety of alcohol nucleophiles. In the case of unactivated electrophiles, such as electron-rich aryl halides, the new ligand L8 was developed to improve these challenging C-O bond-forming reactions.