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RCH-ACV: a lymphoblastic leukemia cell line with chromosome translocation 1;19 and trisomy 8.

Cancer genetics and cytogenetics (1986-01-15)
I Jack, R Seshadri, M Garson, P Michael, D Callen, H Zola, A Morley
RÉSUMÉ

A cell line (RCH-ACV) was established from a bone marrow sample of a child with acute lymphoblastic leukemia (ALL). The cell line lacked Epstein-Barr virus nuclear antigen and exhibited a recently described nonrandom chromosome translocation, 1;19, thought to be associated with pre-B-ALL and poor prognosis. Banding studies confirm that the breakpoint of chromosome #19 occurs at p13.3. Cell surface marker analysis using a panel of monoclonal antibodies revealed markers consistent with common ALL phenotype. Although the cells did not show cytoplasmic immunoglobulin, studies of the immunoglobulin gene rearrangement confirmed the pre-B phenotype. This cell line could be of great value to studies of the role of the specific translocation 1;19 in the etiology of pre-B-ALL.

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Sigma-Aldrich
BLaER1 Human B-cell Precursor Leukemia Cell Line, BLaER1 human B-cell precursor leukemia cell line may be transdifferentiated and used to model human monocytes.