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Documents

T6069

Sigma-Aldrich

Thio-TEPA

Synonyme(s) :

N,N′,N″-Triethylenethiophosphoramide, Thio-Tep, Thiofozil, Thiotef, Tio-tef, Tiofosfamid, Tiofosyl, Tiofozil, Tris(aziridinyl)phosphine sulfide

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About This Item

Formule empirique (notation de Hill):
C6H12N3PS
Numéro CAS:
52-24-4
Poids moléculaire :
189.22
Numéro CE :
200-135-7
Numéro MDL:
MFCD00145452
Code UNSPSC :
51102829
ID de substance PubChem :
24900346
Nomenclature NACRES :
NA.85

Forme

solid

Conditions de stockage

(Keep container tightly closed in a dry and well-ventilated place.)

Couleur

white

Spectre d'activité de l'antibiotique

neoplastics

Mode d’action

DNA synthesis | interferes

Température de stockage

2-8°C

Chaîne SMILES 

S=P(N1CC1)(N2CC2)N3CC3

InChI

1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2

Clé InChI

FOCVUCIESVLUNU-UHFFFAOYSA-N

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Catégories apparentées

Description générale

Chemical structure: aziridine

Application

A polyfunctional alkylating agent

Actions biochimiques/physiologiques

The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division.

Remarque sur l'analyse

Solubility - freely soluble in water , in chloroform and in ethanol (96%)

Autres remarques

Keep container tightly closed in a dry and well-ventilated place.

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Mentions de danger

H300,H350

Classification des risques

Acute Tox. 2 Oral - Carc. 1B

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Michael P Fay et al.
Statistics in medicine, 31(28), 3760-3772 (2012-07-13)
We consider weighted logrank tests for interval censored data when assessment times may depend on treatment, and for each individual, we only use the two assessment times that bracket the event of interest. It is known that treating finite right
Soo Hyeon Bae et al.
Chemico-biological interactions, 205(1), 11-19 (2013-06-20)
The present study was performed to evaluate the potency and specificity of sibutramine as an inhibitor of the activities of nine human CYP isoforms in liver microsomes. Using a cocktail assay, the effects of sibutramine on specific marker reactions of
Ki Woong Sung et al.
Neuro-oncology, 15(3), 352-359 (2012-12-22)
We assessed the feasibility and effectiveness of reduced-dose craniospinal (CS) radiotherapy (RT) followed by tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/autoSCT) in reducing late adverse effects without jeopardizing survival among children with high-risk medulloblastoma (MB). From October 2005
Samuel A Bobholz et al.
Tomography (Ann Arbor, Mich.), 6(2), 160-169 (2020-06-18)
Magnetic resonance (MR)-derived radiomic features have shown substantial predictive utility in modeling different prognostic factors of glioblastoma and other brain cancers. However, the biological relationship underpinning these predictive models has been largely unstudied, and the generalizability of these models had
B Kasenda et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 23(10), 2670-2675 (2012-04-05)
High-dose chemotherapy followed by autologous stem-cell transplantation (HCT-ASCT) is a promising approach in eligible patients with primary central nervous system lymphoma (PCNSL). We report long-term data of patients who were treated according to HCT-ASCT containing protocols. We analyzed survival and
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