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T3766

Sigma-Aldrich

Thymine 1-β-D-arabinofuranoside

≥99%

Synonyme(s) :

araT, 1-β-D-Arabinofuranosylthymine

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About This Item

Formule empirique (notation de Hill):
C10H14N2O6
Numéro CAS:
605-23-2
Poids moléculaire :
258.23
Numéro CE :
210-083-7
Numéro MDL:
MFCD00065474
Code UNSPSC :
41106305
ID de substance PubChem :
24900167
Nomenclature NACRES :
NA.51

Pureté

≥99%

Forme

powder

Activité optique

[α]20/D 90°, c = 5 mg/mL in water

Solubilité

0.5 M HCl: 20 mg/mL, clear, colorless

Température de stockage

2-8°C

Chaîne SMILES 

CC1=CN(C2OC(CO)C(O)C2O)C(=O)NC1=O

InChI

1S/C10H14N2O6/c1-4-2-12(10(17)11-8(4)16)9-7(15)6(14)5(3-13)18-9/h2,5-7,9,13-15H,3H2,1H3,(H,11,16,17)

Clé InChI

DWRXFEITVBNRMK-UHFFFAOYSA-N

Application

1-β-D-Arabinofuranosylthymine (araT):
  • maybe used as a substrate and inhibitor to study the specificity and kinetics of thymidine kinase(s), such as herpes simplex virus type 1 and 2 thymidine kinases, the HSV1-tk and, HSV2-tk gene products.
  • is used to study the specificity and kinetics of various mitochondrial nucleoside kinases.
  • has been used as an antiviral agent to study its efficacy on Cryptosporidium parvum in vitro.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Xiuyun Wang et al.
Nature communications, 11(1), 653-653 (2020-02-02)
The industrial synthesis of ammonia (NH3) using iron-based Haber-Bosch catalyst requires harsh reaction conditions. Developing advanced catalysts that perform well at mild conditions (<400 °C, <2 MPa) for industrial application is a long-term goal. Here we report a Co-N-C catalyst with high
Kristof Y Neven et al.
Scientific reports, 10(1), 161-161 (2020-01-15)
Iodine is an essential trace element, necessary for the production of thyroid hormones, which play a key role in optimal foetal growth and (neuro-) development. To date, iodine deficiency remains a health burden in many countries. We investigated the variability
Efficacy of select antivirals against Cryptosporidium parvum in vitro
Woods KM and Upton SJ
FEMS Microbiology Letters, 168(1), 59-63 (1998)
Alex McAvoy et al.
PLoS computational biology, 11(8), e1004349-e1004349 (2015-08-27)
Evolutionary game theory is a powerful framework for studying evolution in populations of interacting individuals. A common assumption in evolutionary game theory is that interactions are symmetric, which means that the players are distinguished by only their strategies. In nature
Xinyu Zheng et al.
Cancer research, 63(20), 6909-6913 (2003-10-30)
Nucleoside kinases from several species are investigated as suicide genes for treatment of malignant tumors by combined gene/chemotherapy. In the present study, we have investigated a novel strategy where nucleoside kinase proteins are directly delivered to cells without delivery of
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