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SRP4137

Sigma-Aldrich

IL-4 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonyme(s) :

B cell stimulating factor, BCDF, BCGF, BSF-1, IL-4, Lymphocyte stimulatory factor 1

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About This Item

Numéro MDL:
MFCD00151705
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Source biologique

human

Produit recombinant

expressed in E. coli

Pureté

≥98% (HPLC)
≥98% (SDS-PAGE)

Forme

lyophilized

Poids mol.

~15.0 kDa

Conditionnement

pkg of 10 μg

Impuretés

endotoxin, tested

Numéro d'accès NCBI

P05112

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... IL4(3565)

Catégories apparentées

Description générale

The gene IL-4 (interleukin 4) is mapped to human chromosome 5q31.1. Human IL-4 is a 15kDa globular protein containing 130 amino acid residues. It is a cytokine which is mainly secreted by activated Th2 (T helper) cells.

Application

IL-4 (interleukin 4) has been used to polarize the human monocytic leukemia (THP-1) cells to M2-like phenotype.
In inflamed porcine endometrium, IL-4 (interleukin 4)-human has been used to study effects of IL-4 on the leukotriene B4 and leukotriene C4 synthesis as well as secretion. It has been used to study the effect of IL-4 on synthesis and secretion of leukotrienes from endometrial epithelial cells of pigs.

Actions biochimiques/physiologiques

IL-4 (Interleukin 4) is a potent lymphoid cell growth factor that stimulates the growth and survivability of certain B cells and T cells. It exhibits anti-inflammatory responses and participates in immune processes by providing protection from intracellular pathogens. IL-4 also plays an important role in Th2 (T helper cells) differentiation. Additionally, it can suppress pro-inflammatory cytokines. IL-4 is associated with pemphigus. Also, mutation in the gene is linked with risk of dental implant loss. In children, IL-4 might be involved with risk of asthma and Mycoplasma pneumoniae infection.

Forme physique

Sterile filtered and lyophilized with no additives.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations.
Marsh DG, et al.
Science, 264, 1152-1156 (1994)
Shuichi Sakamoto et al.
Oncoimmunology, 8(12), e1671760-e1671760 (2019-11-20)
A solid tumor consists of cancer and stromal cells, which comprise the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) are usually abundant in the TME, contributing to tumor progression. In cases of peritoneal dissemination of gastric cancer (GC), the contribution of
Interleukin 4 inhibition as a potential therapeutic in pemphigus.
Tavakolpour S and Tavakolpour V
Cytokine, 77, 189-195 (2016)
Association of interleukin 4 gene polymorphisms with dental implant loss.
Pigossi SC, et al.
Implant Dentistry, 23, 723-731 (2014)
Purification of a 130-kDa T cell glycoprotein that binds human interleukin 4 with high affinity.
Galizzi JP, et al.
The Journal of Biological Chemistry, 265, 439-444 (1990)
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