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SML0508

Sigma-Aldrich

Pentostatin

≥95% (HPLC)

Synonyme(s) :

(8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, 2′-dCF, DCF, Deoxycoformycin

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About This Item

Formule empirique (notation de Hill):
C11H16N4O4
Numéro CAS:
53910-25-1
Poids moléculaire :
268.27
Code UNSPSC :
12352200
ID de substance PubChem :
329825517
Nomenclature NACRES :
NA.77

Pureté

≥95% (HPLC)

Forme

powder

Activité optique

[α]/D +70 to +80°, c = 1 in H2O

Conditions de stockage

desiccated

Couleur

white to beige

Solubilité

H2O: 10 mg/mL, clear

Conditions d'expédition

wet ice

Température de stockage

−20°C

Chaîne SMILES 

OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3[C@H](O)CN=CNc23

InChI

1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1

Clé InChI

FPVKHBSQESCIEP-JQCXWYLXSA-N

Informations sur le gène

human ... ADA(100)

Application

Pentostatin has been used in in vivo anti-tumor studies. It has also been used along with cyclophosphamide as a selective B-cell immune suppression regimen to explore solid tumor therapy by selectively targeting stromal endothelial cells.

Actions biochimiques/physiologiques

Pentostatin is a ring-expanded nucleoside (REN) that potently inhibits adenosine deaminase, which leads to lymphocyte toxicity. Pentostatin is used as anticancer agent to treat leukemia (hairy cell leukemia and chronic lymphocytic leukemia) and is investigated as an agent to treat graft-versus-host disease (GVHD).
Pentostatin/2′-deoxycoformycin is used to treat patients with Waldenström′s macroglobulinemia.

Caractéristiques et avantages

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Autres remarques

Air sensitve; hygroscopic.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301

Classification des risques

Acute Tox. 3 Oral

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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