P4157

Phe-Arg β-naphthylamide dihydrochloride

cathepsin substrate, fluorogenic, ≥98% (TLC), powder

• Synonyme(s) : PAβN
• Formule empirique (notation de Hill): C₂₅H₃₀N₆O₂ · 2HCl
• Numéro CAS: 100929-99-5
• Poids moléculaire : 519.47
• Numéro MDL: MFCD00058046
• Code UNSPSC : 12352204
• ID de substance PubChem : 24898508
• Nomenclature NACRES : NA.32

Propriétés

• product name: Phe-Arg β-naphthylamide dihydrochloride, cathepsin substrate
• Pureté: ≥98% (TLC)
• Forme: powder
• Solubilité: water: 50 mg/mL, clear, colorless to faintly yellow
• Température de stockage: −20°C
• Chaîne SMILES: Cl.NC(Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)Nc2ccc3ccccc3c2
• InChI: 1S/C25H30N6O2.ClH/c26-21(15-17-7-2-1-3-8-17)23(32)31-22(11-6-14-29-25(27)28)24(33)30-20-13-12-18-9-4-5-10-19(18)16-20;/h1-5,7-10,12-13,16,21-22H,6,11,14-15,26H2,(H,30,33)(H,31,32)(H4,27,28,29);1H
• Clé InChI: ZMTAZQYLEGNUTJ-UHFFFAOYSA-N

Description

Description générale

Phe-Arg β-naphthylamide, a peptidomimetic compound, is an efflux pump inhibitor (EPI). It acts on the major multidrug resistance efflux transporters of Gram-negative bacteria. Phe-Arg -naphthylamide lowers fluoroquinolone resistance in Pseudomonas aeruginosa.

Application

Phe-Arg -naphthylamide dihydrochloride has been used to evaluate the contribution of efflux pumps to antimicrobial resistance. It has also been used for minimal inhibitory concentration testing in the presence of an efflux pump inhibitor.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Substrats

Substrate for dipeptidyl aminopeptidase I (cathepsin C).

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)