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P0022

Sigma-Aldrich

PS48

≥98% (HPLC)

Synonyme(s) :

5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid

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About This Item

Formule empirique (notation de Hill):
C17H15ClO2
Numéro CAS:
1180676-32-7
Poids moléculaire :
286.75
Numéro MDL:
MFCD17215962
Code UNSPSC :
12352200
ID de substance PubChem :
329819977
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

powder

Conditions de stockage

protect from light

Couleur

white to off-white

Solubilité

DMSO: >20 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

OC(=O)\C=C(\CCc1ccc(Cl)cc1)c2ccccc2

InChI

1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12-

Clé InChI

LLJYFDRQFPQGNY-QINSGFPZSA-N

Actions biochimiques/physiologiques

PS48 is a PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of only a few truly allosteric compounds targeting a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlapping with the ATP-binding site.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Mito Kanatsu-Shinohara et al.
The Journal of reproduction and development, 64(6), 511-522 (2018-09-04)
Stem cell homing is a complex phenomenon that involves multiple steps; thus far, attempts to increase homing efficiency have met with limited success. Spermatogonial stem cells (SSCs) migrate to the niche after microinjection into seminiferous tubules, but the homing efficiency
Satoshi Watanabe et al.
Biology of reproduction, 100(2), 523-534 (2018-08-31)
Spermatogonial stem cells (SSCs) provide the foundation of spermatogenesis. However, because of their small number and slow self-renewal, transfection of SSCs has met with limited success. Although several viral vectors can infect SSCs, genome integration and an inability to maintain
Rui Sun et al.
Cellular and molecular gastroenterology and hepatology, 11(1), 249-272 (2020-08-23)
TNFSF15 genetic variants leading to increased TNF superfamily member 15 (TNFSF15) expression confer risk for inflammatory bowel disease (IBD), and TNFSF15 is being explored as a therapeutic target in IBD patients. Although the focus for TNFSF15-mediated inflammatory outcomes has been
Shun Watanabe et al.
Pflugers Archiv : European journal of physiology, 468(4), 667-677 (2015-11-19)
Hyperinsulinemia associated with type 2 diabetes may contribute to the development of vascular diseases. Although we recently reported that enhanced contractile responses to serotonin (5-hydroxytryptamine, 5-HT) are observed in the arteries of type 2 diabetes models, the causative factors and
Steven B Daines et al.
The Journal of arthroplasty, 32(1), 274-279 (2016-08-16)
Increased range of motion to higher degrees of flexion following total knee arthroplasty has been postulated to increase implant damage and revision rates, even in designs modified to accommodate high flexion. We examined posterior-stabilized and high-flexion retrieved tibial inserts to
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