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A4941

Sigma-Aldrich

Activin A human

≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture

Synonyme(s) :

Activin A Protein, Growth Factor, Human Growth Factor

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About This Item

Numéro CE :
201-069-1
Numéro MDL:
MFCD02685750
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

product name

Activin A human, ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture

Source biologique

human

Niveau de qualité

200

Produit recombinant

expressed in baculovirus infected insect cells

Pureté

≥95% (SDS-PAGE)

Forme

lyophilized powder

Puissance

1-10 ng/mL ED50

Poids mol.

dimer 26 kDa (containing 116 amino acid residues βA subunits)

Conditionnement

pkg of 10 μg
pkg of 5 μg

Technique(s)

cell culture | mammalian: suitable

Impuretés

endotoxin, tested

Numéro d'accès UniProt

P08476

Température de stockage

−20°C

Informations sur le gène

human ... INHBA(3624)

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Description générale

Activin A gene with two exons is mapped to human chromosome 2q35. Activin A also known as inhibin α-subunit belongs to the TGF-β (transforming growth factor-β) superfamily of proteins and its expression is exclusive to gonads, placenta and adrenal cortex.

Application

Activin A human has been used as a constituent of modified barth′s saline used in in vitro induction of pronephros. It has also been used as a constituent of Roswell Park memorial institute (RPMI) media to induce pancreatic differentiation of multipotent dermal fibroblasts in vitro.

Actions biochimiques/physiologiques

Activins play a vital role in the regulation of hormonogenesis, cellular homeostasis and differentiation programs. Elevated expression of activin A and B leads to the loss of muscle mass. Both activin A and B have a potential to act as a serum markers of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).

Forme physique

Lyophilized from 0.2 μm filtered solution in 10 mM sodium citrate, pH 3.0.

Remarque sur l'analyse

The biological activity is determined by its ability to inhibit the proliferation of mouse MPC-11 cells.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H319,H335

Classification des risques

Eye Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Inhibin Alpha-Subunit (INHA) Expression in Adrenocortical Cancer Is Linked to Genetic and Epigenetic INHA Promoter Variation
Hofland J, et al.
PLoS ONE, 9, e104944-e104944 (2014)
Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: a cross sectional study
Lidbury BA, et al.
Journal of Translational Medicine, 15 (2017)
Differentiation of human multipotent dermal fibroblasts into islet-like cell clusters
Bi D, et al.
BMC Cell Biology, 11, 1-7 (2010)
T K Woodruff
Biochemical pharmacology, 55(7), 953-963 (1998-05-30)
Activin is an important molecule that regulates hormonogenesis, cellular homeostasis (divide or die pathways), and differentiation programs (developmentally and in adult cells). The cellular mechanisms that integrate an activin signal into a physiological response include a binary receptor complex and
Valérie Bello et al.
Developmental biology, 317(1), 106-120 (2008-04-02)
Dystroglycan (Dg) is a laminin receptor that is expressed at the interface between the basement membrane and the cell membrane. Dg has been reported to play a role in skeletal muscle cell stability, morphogenesis of neuroepithelial tissues, and in regulating
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