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A2504

Sigma-Aldrich

6-Aminocaproic acid

≥99% (titration), powder

Synonyme(s) :

ε-Aminocaproic acid, 6-Aminohexanoic acid, EACA

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About This Item

Formule linéaire :
H2N(CH2)5CO2H
Numéro CAS:
60-32-2
Poids moléculaire :
131.17
Numéro Beilstein :
906872
Numéro CE :
200-469-3
Numéro MDL:
MFCD00008238
Code UNSPSC :
12352202
ID de substance PubChem :
24890662
Nomenclature NACRES :
NA.77

Source biologique

synthetic

Pureté

≥99% (titration)

Forme

powder

Technique(s)

cell culture | mammalian: suitable

Couleur

white

Pf

207-209 °C (dec.) (lit.)

Solubilité

H2O: 50 mg/mL

Chaîne SMILES 

NCCCCCC(O)=O

InChI

1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)

Clé InChI

SLXKOJJOQWFEFD-UHFFFAOYSA-N

Informations sur le gène

human ... PLAT(5327) , PLG(5340)
rat ... Ppm1a(24666)

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Catégories apparentées

Application

EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.

Actions biochimiques/physiologiques

EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo­xy­peptidase, plasmin, and plasminogen activator.
Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

404.6 - 408.2 °F

Point d'éclair (°C)

207 - 209 °C

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Kazuki Yamamoto et al.
Lab on a chip, 21(10), 1897-1907 (2021-05-20)
Engineered three-dimensional models of neuromuscular tissues are promising for use in mimicking their disorder states in vitro. Although several models have been developed, it is still challenging to mimic the physically separated structures of motor neurons (MNs) and skeletal muscle
E M Van Hoeyveld et al.
The Journal of allergy and clinical immunology, 76(4), 543-550 (1985-10-01)
The effect of epsilon-aminocaproic acid (EACA) on the degradation of an aqueous Lolium perenne extract was studied by intracutaneous tests and by RAST inhibition. Extracts for skin testing stored at 4 degrees C for 12 months and at 37 degrees
Brian Hutton et al.
BMJ (Clinical research ed.), 345, e5798-e5798 (2012-09-13)
To estimate the relative risks of death, myocardial infarction, stroke, and renal failure or dysfunction between antifibrinolytics and no treatment following the suspension of aprotinin from the market in 2008 for safety reasons and its recent reintroduction in Europe and
Moamen Bydoun et al.
Molecular oncology, 12(11), 1895-1916 (2018-07-17)
Pancreatic cancer is arguably the deadliest cancer type. The efficacy of current therapies is often hindered by the inability to predict patient outcome. As such, the development of tools for early detection and risk prediction is key for improving outcome
María D Valls et al.
Frontiers in pharmacology, 12, 654104-654104 (2021-05-15)
Adenosine A2A receptor mediates the promotion of wound healing and revascularization of injured tissue, in healthy and animals with impaired wound healing, through a mechanism depending upon tissue plasminogen activator (tPA), a component of the fibrinolytic system. In order to
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