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A2027

Sigma-Aldrich

L-Arginine-7-amido-4-methylcoumarin hydrochloride

cathepsin H substrate

Synonyme(s) :

Arginine 4-methyl-7-coumarylamide

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About This Item

Formule empirique (notation de Hill):
C16H21N5O3
Numéro CAS:
69304-16-1
Poids moléculaire :
331.37
Numéro MDL:
MFCD00058184
Code UNSPSC :
12352204
ID de substance PubChem :
24890618
Nomenclature NACRES :
NA.83

Pureté

≥97% (TLC)

Forme

powder

Solubilité

acetic acid: water (1:1): 50 mg/mL, clear, colorless to light yellow

Température de stockage

−20°C

Chaîne SMILES 

Cl.CC1=CC(=O)Oc2cc(NC(=O)[C@@H](N)CCCNC(N)=N)ccc12

InChI

1S/C16H21N5O3.ClH/c1-9-7-14(22)24-13-8-10(4-5-11(9)13)21-15(23)12(17)3-2-6-20-16(18)19;/h4-5,7-8,12H,2-3,6,17H2,1H3,(H,21,23)(H4,18,19,20);1H/t12-;/m0./s1

Clé InChI

PFLMUQNBZRXRHD-YDALLXLXSA-N

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Application

L-Arginine-7-amido-4-methylcoumarin hydrochloride has been used as a substrate for cathepsin H from rat muscle homogenate and sarcoplasmic extract. It has also been used as a substrate for arginine amino-peptidase from Daphnia homogenates and recombinant aminopeptidase from Toxoplasma gondii.

Actions biochimiques/physiologiques

L-Arginine-7-amido-4-methylcoumarin hydrochloride is a protease substrate. It is a specific substrate for cathepsin H and not for cathepsin L and B.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Cachexia syndrome can affect cancer patients and new prevention strategies are required. Maternal nutritional supplementation can modify metabolic programming in the offspring, which lasts until adulthood. This could be a good approach against diseases such as cancer. A 3% leucine-rich
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