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Key Documents

449R-1

Sigma-Aldrich

S100 beta (EP32) Rabbit Monoclonal Primary Antibody

Synonyme(s) :

S100 Calcium Binding Protein B

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About This Item

Code UNSPSC :
12352203

Source biologique

rabbit

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

EP32, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (449R-14)
vial of 0.1 mL concentrate Research Use Only (449R-14-RUO)
vial of 0.5 mL concentrate (449R-15)
vial of 1.0 mL concentrate (449R-16)
vial of 1.0 mL concentrate Research Use Only (449R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (449R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (449R-17)
vial of 7.0 mL pre-dilute ready-to-use (449R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (449R-18-RUO)

Fabricant/nom de marque

Cell Marque™

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)

Isotype

IgG

Contrôle

melanoma

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

cytoplasmic

Description générale

S100 calcium binding protein B (S100 beta) is a member of the multifunctional S100 family of proteins. S100 beta acts as a stimulator of proliferation and migration and as an inhibitor of apoptosis and differentiation in many cell types including astrocytes, Schwann cells, chondrocytes, adipocytes, certain neuronal populations, melanocytes, Langerhans cells, histiocytes, epithelial, and myoepithelial cells. S100 beta is also expressed in neoplasms derived from these cell types, making it a useful marker for the identification of melanoma and various nervous system tumors. Although ubiquitous, S100 beta has proven to be a sensitive marker for malignant melanoma, including desmoplastic and metastatic variants.

Qualité


IVD
IVD
IVD
RUO

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Notes préparatoires

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Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

R Donato et al.
Current molecular medicine, 13(1), 24-57 (2012-07-28)
The S100 protein family consists of 24 members functionally distributed into three main subgroups: those that only exert intracellular regulatory effects, those with intracellular and extracellular functions and those which mainly exert extracellular regulatory effects. S100 proteins are only expressed
F Sedaghat et al.
Hippokratia, 12(4), 198-204 (2009-01-23)
The members of the S100 protein family are multifunctional proteins with a regulatory role in a variety of cellular processes. They exert their actions usually through calcium binding, although Zn2+ and Cu2+ have also been shown to regulate their biological
C deBlacam et al.
British journal of cancer, 105(1), 118-123 (2011-06-10)
Cutaneous melanoma is an aggressive disease. S100beta is an established biomarker of disease progression; however, the mechanism of its regulation in melanoma is undefined. Expression of HOXC11 and SRC-1 was examined by immunohistochemistry and immunofluorescence. Molecular and cellular techniques were
Markku Miettinen et al.
The American journal of surgical pathology, 38(3), 410-420 (2014-02-15)
The SALL4 transcription factor is associated with embryonic cell pluripotency and has been shown as a useful immunohistochemical marker for germ cell tumors. However, information of SALL4 distribution in normal human tissues and non-germ cell tumors is limited. In this

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