290M-1
MUC1 (MRQ-17) Mouse Monoclonal Antibody
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Niveau de qualité
100
500
Conjugué
unconjugated
Forme d'anticorps
culture supernatant
Type de produit anticorps
primary antibodies
Clone
MRQ-17, monoclonal
Description
For In Vitro Diagnostic Use in Select Regions (See Chart)
Forme
buffered aqueous solution
Espèces réactives
human
Conditionnement
vial of 0.1 mL concentrate (290M-14)
vial of 0.5 mL concentrate (290M-15)
bottle of 1.0 mL predilute (290M-17)
vial of 1.0 mL concentrate (290M-16)
bottle of 7.0 mL predilute (290M-18)
Fabricant/nom de marque
Cell Marque™
Technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
Isotype
IgG1
Contrôle
breast
Conditions d'expédition
wet ice
Température de stockage
2-8°C
Visualisation
cytoplasmic
Informations sur le gène
human ... MUC1(4582)
Description générale
Mucins are high molecular weight glycoproteins which constitute the major component of the mucus layer that protects the gastric epithelium from chemical and mechanical aggressions. In humans, at least 14 mucin genes have been identified that code for the mucin proteins. They are designated as MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6, MUC7, MUC8, MUC9, MUC11, MUC12, MUC13, and MUC16.
The heterogeneous pattern of mucin expression, including the expression of the intestinal mucin MUC2, may provide new insights into the differentiation pathways of gastric carcinoma. Pinto-de-Sousa et al. have shown in a comprehensive study of gastric carcinomas evaluated for expression of several mucins (MUC1, MUC2, MUC5AC and MUC6) that: (1) mucin expression is associated with tumor type (MUC5AC with diffuse and infiltrative carcinomas and MUC2 with mucinous carcinomas) but not with the clinico-biological behavior of the tumors; and (2) mucin expression is associated with tumor location (MUC5AC with antrum carcinomas and MUC2 with cardia carcinomas), indirectly reflecting differences in tumor differentiation according to tumor location.
The following generalities apply to the patterns of Mucin expression:
MUC1 expression: apical surfaces of most epithelial cells in breast, GI, respiratory, and GU tracts.
Associated products: MUC2, MUC5AC, MUC6, TAG-72, MOC-31, CEA
The heterogeneous pattern of mucin expression, including the expression of the intestinal mucin MUC2, may provide new insights into the differentiation pathways of gastric carcinoma. Pinto-de-Sousa et al. have shown in a comprehensive study of gastric carcinomas evaluated for expression of several mucins (MUC1, MUC2, MUC5AC and MUC6) that: (1) mucin expression is associated with tumor type (MUC5AC with diffuse and infiltrative carcinomas and MUC2 with mucinous carcinomas) but not with the clinico-biological behavior of the tumors; and (2) mucin expression is associated with tumor location (MUC5AC with antrum carcinomas and MUC2 with cardia carcinomas), indirectly reflecting differences in tumor differentiation according to tumor location.
The following generalities apply to the patterns of Mucin expression:
MUC1 expression: apical surfaces of most epithelial cells in breast, GI, respiratory, and GU tracts.
Associated products: MUC2, MUC5AC, MUC6, TAG-72, MOC-31, CEA
Qualité
 IVD |  IVD |  IVD |  RUO |
Liaison
MUC1 Positive Control Slides, Product No. 290S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Forme physique
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Notes préparatoires
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Autres remarques
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Informations légales
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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T Mizoshita et al.
Histology and histopathology, 22(3), 251-260 (2006-12-14)
We have previously demonstrated links between clinicopathological findings and phenotypes using several gastric and intestinal phenotypic markers in stomach and pancreatic cancers. However, the clinicopathological significance of the phenotype and Cdx2 expression has hitherto remained unclear in colorectal carcinogenesis. We
P Chaves et al.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 18(6), 383-387 (2005-12-13)
Intestinal metaplasia is a prerequisite criterion for the diagnosis of Barrett's metaplasia and the sole columnar esophageal lining associated with malignancy. It is recognized by the presence of goblet cells, but columnar non-goblet elements, producing gastric or intestinal proteins, are
Fionnuala P O'Connell et al.
Archives of pathology & laboratory medicine, 129(3), 338-347 (2005-03-02)
Breast carcinoma often metastasizes to the gastrointestinal tract, especially the stomach, where it is frequently difficult to distinguish from a primary gastric carcinoma. To evaluate the utility of immunohistochemical stains in differentiating primary gastric carcinomas from metastatic breast carcinomas. Mucosal
Emmanuelle Leteurtre et al.
World journal of gastroenterology, 12(21), 3324-3331 (2006-05-31)
To investigate the expression of the four secreted gel-forming mucins (MUC2, MUC5AC, MUC5B and MUC6) in a series of gastric carcinomas, classified according Lauren's, Mulligan's, WHO and Goseki's classifications, with special attention to all the different components (major and minor)
Mari Mino-Kenudson et al.
Archives of pathology & laboratory medicine, 131(1), 86-90 (2007-01-18)
Reactive gastropathy is the second most common diagnosis made on gastric biopsies. Increased epithelial proliferation and modifications of epithelial cytokeratin profile, distinct from those of Helicobacter pylori gastritis, have been previously reported. However, the evaluation of mucins, important components of
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