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04276

Sigma-Aldrich

Phosphate de sodium dibasic

puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, E 339, anhydrous, 98-100.5% (calc. to the dried substance)

Synonyme(s) :

Phosphate de sodium secondaire, Hydrogénophosphate de disodium, Hydrogénophosphate de sodium, Phosphate disodique

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About This Item

Formule linéaire :
Na2HPO4
Numéro CAS:
7558-79-4
Poids moléculaire :
141.96
Numéro CE :
231-448-7
Numéro MDL:
MFCD00003496
Code UNSPSC :
12161700
eCl@ss :
38070211
ID de substance PubChem :
329747909
Nomenclature NACRES :
NA.25

Agence

meets analytical specifications of BP
meets analytical specifications of Ph. Eur.
meets analytical specifications of USP

Qualité

puriss.
meets analytical specification of Ph. Eur., BP, USP, FCC, E 339

Pureté

98-100.5% (calc. to the dried substance)

Forme

powder

Impuretés

reducing matter, complies
 residual solvents, complies
≤0.001% heavy metals (as Pb)
≤0.002% ammonium (NH4)
≤0.2% water-insoluble matter
≤1% NaH2PO4 (calc. to dried subst.)
≤2.0% pyrophosphate (as Na4P2O7)

Perte

≤1% loss on drying, 105°C, 4h
≤1% loss on drying, 130 °C

pH

8.4-9.6 (20 °C, 1%)

pKa (25 °C)

(1) 2.15, (2) 6.82, (3) 12.38 (phosphoric acid)

Solubilité

H2O: soluble 8 parts
H2O: very soluble (Hot)
alcohol: insoluble

Traces d'anions

chloride (Cl-): ≤50 mg/kg
fluoride (F-): ≤10 mg/kg
sulfate (SO42-): ≤200 mg/kg

Traces de cations

As: ≤2 mg/kg
Cd: ≤1 mg/kg
Cu: ≤10 mg/kg
Fe: ≤20 mg/kg
Hg: ≤1 mg/kg
Pb: ≤4 mg/kg
Zn: ≤10 mg/kg

Adéquation

complies for appearance of solution

Chaîne SMILES 

[Na+].[Na+].[H]OP([O-])([O-])=O

InChI

1S/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-2

Clé InChI

BNIILDVGGAEEIG-UHFFFAOYSA-L

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Application

Sodium phosphate dibasic has been used for preparing phosphate buffer which in turn is utilized in X-gal staining.

Actions biochimiques/physiologiques

Sodium phosphate dibasic is an important component of running buffer of denaturing gel electrophoresis. It induces glomerular calcification as well as other nephrotic syndrome in Sprague-Dawley rats.

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Consulter la Bibliothèque de documents

Noriko Tsuchiya et al.
Toxicologic pathology, 32(4), 408-412 (2004-06-19)
To elucidate the nephrotoxicity of phosphate, dibasic sodium phosphate solution was given to Sprague-Dawley rats by daily bolus intravenous administration at concentrations of 0, 1, 25, 250, or 360 mM (0, 1, 28, 284, or 408 mg/kg Na2HPO4) for 14
B Duvillié et al.
Endocrinology, 143(4), 1530-1537 (2002-03-19)
The targeted disruption of the two nonallelic insulin genes in mouse was reported previously to result in intrauterine growth retardation, severe diabetes immediately after suckling, and death within 48 h of birth. We have further used these animals to investigate
Noriko Tsuchiya et al.
Toxicologic pathology, 37(3), 270-279 (2009-02-27)
Sprague-Dawley rats received once daily tail-vein injections of 360 mM dibasic sodium phosphate solution at 8 mL/kg for fourteen or twenty-eight days. Clinical examination revealed persistent proteinuria from three days after the first dosing and thereafter severe proteinuria from eight
Samuel Adler et al.
Gastrointestinal endoscopy, 76(6), 1170-1174 (2012-10-03)
Colon capsule endoscopy (CCE) is a noninvasive technique for the detection of colorectal lesions. However, for CCE to be offered as an out-of-clinic procedure, the system needs to automatically alert the patient when to ingest the laxative (booster). We tested
Megan A Rees et al.
Journal of proteome research, 14(1), 120-132 (2014-10-21)
Interactions between a host and a bacterial pathogen are mediated by cross-talk between molecules present on, or secreted by, pathogens and host binding-molecules. Identifying proteins involved at this interface would provide substantial insights into this interaction. Although numerous studies have
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