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Key Documents

E1310000

Erythromycin B

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

12-Deoxyerythromycin

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About This Item

Formule empirique (notation de Hill):
C37H67NO12
Numéro CAS:
527-75-3
Poids moléculaire :
717.93
Code UNSPSC :
41116107
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

erythromycin

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

InChI

1S/C37H67NO12/c1-14-26-20(4)29(40)21(5)28(39)18(2)16-36(9,44)33(50-35-30(41)25(38(11)12)15-19(3)46-35)22(6)31(23(7)34(43)48-26)49-27-17-37(10,45-13)32(42)24(8)47-27/h18-27,29-33,35,40-42,44H,14-17H2,1-13H3/t18-,19?,20+,21+,22?,23-,24?,25?,26-,27?,29+,30?,31+,32?,33-,35?,36-,37?/m1/s1

Clé InChI

IDRYSCOQVVUBIJ-ZTOAHLHUSA-N

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Erythromycin B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

PHR1039

Erythromycin, Pharmaceutical Secondary Standard; Certified Reference Material

1242000

Erythromycin, United States Pharmacopeia (USP) Reference Standard

1242010

Erythromycin B, United States Pharmacopeia (USP) Reference Standard

1242021

Erythromycin C, United States Pharmacopeia (USP) Reference Standard

1242032

Erythromycin Related Compound N, United States Pharmacopeia (USP) Reference Standard

1245008

Erythromycin ethyl succinate, United States Pharmacopeia (USP) Reference Standard

E1320000

Erythromycin C, European Pharmacopoeia (EP) Reference Standard

E1400000

Erythromycin estolate, European Pharmacopoeia (EP) Reference Standard

E1500000

Erythromycin ethyl succinate, European Pharmacopoeia (EP) Reference Standard

E1300000

Erythromycin, for microbiological assay, European Pharmacopoeia (EP) Reference Standard

E1500800

Erythromycin stearate, European Pharmacopoeia (EP) Reference Standard

1243002

Erythromycin estolate, United States Pharmacopeia (USP) Reference Standard

1248006

Erythromycin stearate, United States Pharmacopeia (USP) Reference Standard

1247003

Erythromycin lactobionate, United States Pharmacopeia (USP) Reference Standard

PHR1610

Erythromycin Ethylsuccinate, Pharmaceutical Secondary Standard; Certified Reference Material

BP488

Erythromycin stearate, British Pharmacopoeia (BP) Reference Standard

BP781

Erythromycin, British Pharmacopoeia (BP) Reference Standard

BP889

N-Demethylerythromycin A, British Pharmacopoeia (BP) Reference Standard

BP798

Erythromycin ethyl succinate, British Pharmacopoeia (BP) Reference Standard

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H319

Conseils de prudence

P305 + P351 + P338

Classification des risques

Eye Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

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Certificats d'analyse (COA)

Lot/Batch Number

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An abiotic strategy for the enantioselective synthesis of erythromycin B.
Paul J Hergenrother et al.
Angewandte Chemie (International ed. in English), 42(28), 3278-3281 (2003-07-24)
Q Zhang et al.
Letters in applied microbiology, 52(2), 129-137 (2010-12-24)
To overproduce erythromycin C, B or D and evaluate the effect of disruption of tailoring genes eryK and eryG in an industrial erythromycin producer. The tailoring genes eryG and eryK were inactivated individually or simultaneously by targeted gene disruption in
M S Brown et al.
The Journal of antibiotics, 52(8), 742-747 (1999-12-02)
Cyclopropane carboxylic acid was fed to Saccharopolyspora erythraea NRRL 18643 (6-deoxyerythromycin producer), resulting in the production of 6-deoxy-13-cyclopropyl-erythromycin B. These studies provide further evidence that deoxyerythronolide B synthase has a relaxed specificity for the starter unit.
Beom Seok Kim et al.
Biochemistry, 41(35), 10827-10833 (2002-08-28)
An unusual feature of the 6-module pikromycin polyketide synthase (PikPKS, PikAI-PikAIV) of S. venezuelae is the ability to generate both 12- and 14-membered ring macrolides. The PikAIV component containing the last extension module and a thioesterase domain is responsible for
Pranab K Bhadra et al.
Journal of medicinal chemistry, 48(11), 3878-3884 (2005-05-27)
Erythromycin A is normally formulated for children as its 2'-ethyl succinate, a taste-free prodrug. Unfortunately, the prodrug hydrolyzes at a measurable rate in the medicine bottle, leading to the vile-tasting erythromycin. We have prepared derivatives of erythromycin B as putative
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