91204
Acetic anhydride
for GC derivatization, LiChropur™, ≥99.0%
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About This Item
Formule linéaire :
(CH3CO)2O
Numéro CAS:
Poids moléculaire :
102.09
Numéro Beilstein :
385737
Numéro CE :
Numéro MDL:
Code UNSPSC :
12000000
ID de substance PubChem :
Nomenclature NACRES :
NA.22
Produits recommandés
Qualité
for GC derivatization
LiChropur™
Niveau de qualité
Densité de vapeur
3.5 (vs air)
Pression de vapeur
10 mmHg ( 36 °C)
4 mmHg ( 20 °C)
Pureté
≥99.0% (GC)
≥99.0%
Forme
liquid
Température d'inflammation spontanée
629 °F
Limite d'explosivité
10.3 %
Pertinence de la réaction
reagent type: derivatization reagent
reaction type: Acylations
Technique(s)
gas chromatography (GC): suitable
Résidus d'évap.
≤0.003%
Indice de réfraction
n20/D 1.390 (lit.)
Point d'ébullition
138-140 °C (lit.)
Pf
−73 °C (lit.)
Solubilité
H2O: slightly soluble
Densité
1.08 g/mL (lit.)
Chaîne SMILES
CC(=O)OC(C)=O
InChI
1S/C4H6O3/c1-3(5)7-4(2)6/h1-2H3
Clé InChI
WFDIJRYMOXRFFG-UHFFFAOYSA-N
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Description générale
Acetic anhydride is an esterification agent which is corrosive to metals. It is a colourless liquid with strong vinegar-like odour. It is mostly used in making plastics, fibers, pharmaceuticals, dyes and explosives.
Acylation, an alternative to silylation, enables the conversion of compounds that comprise of active hydrogens (-OH, -SH and -NH) into esters, thioesters, and amides by the action of a carboxylic acid or derivative. The carbonyl group adjacent to the halogenated carbons favors the improvement of electron capture detector (ECD) response. Acylation has several benefits:
Acetic anhydride is a reagent utilized to form fragmentation-directing derivatives for GC/MS analysis.
- It increases the stability of compounds by protecting unstable groups.
- It may render volatility on substances like carbohydrates or amino acids, that have several polar groups that they are non-volatile and generally decompose on heating.
- It allows the separations not possible with underivatized compounds.
- Compounds are detectable at very low levels with an ECD.
Acetic anhydride is a reagent utilized to form fragmentation-directing derivatives for GC/MS analysis.
Application
Learn more in the Product Information
Suitable for the derivatization of acetyl, acetaminophen, alcohols, aldoses and partially methylated aldoses, aldosterone, amines, amino acids, amino sugars (in polysaccharides), amino sugar methyl glycosides, 2-amino-2-deoxyhexoses, arginyl peptides, aryl sulfate esters, bile acids, carbamates, carbohydrates, cerebrosides, cystine and cysteine (in peptides), desmethyldoxepin, 3,4-dihydroxyphenylglycol, estrogens, glycitols, hexopyranosides, hexosamines, hydroxamic acids, hydroxyamines, n-hydroxycarbamates, hydroxy steroids, inositols, 4-methoxy and 3,4-dimethoxyphenethylamine, methyl ester, methyl(methyl O-methyl-a-D-glucopyranosid)uronates, nucleosides, nucleoside bases and sugars, partially methylated pentose and hexoes, peptides, phenolalkylamines, phenylethylamines, polysaccharide constituents, postaglandins A,B and E, serotonin, sialic acids, sugars, natural sugars and tryptamine.
Autres remarques
Reagent for acetic anhydride, acetyl, n-acetyl, n-acetyl-n, o-acetyl, acetate, aldononitrile acetate, aminoglycitol acetate, aryl acetate, permethyl acetyl, methyl ester, trifluoroacetyl, bis-trimethylsilyl, trimethylsilyl polyamino alcohol, and O-trimethylsilyl (TMS).
Informations légales
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Mention d'avertissement
Danger
Mentions de danger
Classification des risques
Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B
Code de la classe de stockage
3 - Flammable liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
120.2 °F - closed cup
Point d'éclair (°C)
49 °C - closed cup
Équipement de protection individuelle
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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