SCC115
CH27 Mouse B Cell Lymphoma Cell Line
Mouse
Synonyme(s) :
CH27 [Mouse lymphoma]
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About This Item
Code UNSPSC :
41106514
eCl@ss :
32011203
Nomenclature NACRES :
NA.81
Produits recommandés
product name
CH27 Mouse B Cell Lymphoma Cell Line, CH27 mouse B cell lymphoma celll line is a useful model for the study of B-cell biology and tumor immunology.
Source biologique
mouse
Niveau de qualité
Conditions d'expédition
ambient
Description générale
CH27 Mouse B Cell Lymphoma Cell Line is one of the CH series of mouse B-cell lymphomas that arise from the spleen cells of B10.H-2a-H-4b p/Wts (2a4b) mice, either spontaneously or after transplantation of the spleen cells to syngeneic or F1 hybrid recipients .
CH27 cells express surface IgM and Ia antigens along with Ly-1 (CD5) and Ig which bind sheep (SRBC) and chicken erythrocytes and bromelain-treated mouse erythrocytes . The hapten recognized by SRBC-binding CH lymphomas is a phospholipid, either phosphatidylchone or sphingomyelin . Phospholipids are a common component of cell membranes and thus cells expressing immunoglobulin with specificity for SRBC can also be found in the spleens of normal mice . This suggests that CH lymphomas represent neoplastic analogues of Ly-1+ normal B-cells .
CH27 cells express surface IgM and Ia antigens along with Ly-1 (CD5) and Ig which bind sheep (SRBC) and chicken erythrocytes and bromelain-treated mouse erythrocytes . The hapten recognized by SRBC-binding CH lymphomas is a phospholipid, either phosphatidylchone or sphingomyelin . Phospholipids are a common component of cell membranes and thus cells expressing immunoglobulin with specificity for SRBC can also be found in the spleens of normal mice . This suggests that CH lymphomas represent neoplastic analogues of Ly-1+ normal B-cells .
Description de la lignée cellulaire
Cancer Cells
Application
Research Category
Cancer
Immune Response
Inflammation & Immunology
Cancer
Immune Response
Inflammation & Immunology
This product is intended for sale and sold solely for internal non-commercial research use per the terms of the “Restricted Use Agreement” as detailed in the product documentation. For information regarding any other uses, please contact licensing@emdmillipore.com.
Qualité
• Each vial contains ≥ 1X106 viable cells.
• Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination
• Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination
Stockage et stabilité
Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
does not flash
Point d'éclair (°C)
does not flash
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Transplantable B-cell lymphomas in B10. H-2aH-4bp/Wts mice.
L L Lanier et al.
Immunogenetics, 16(4), 367-371 (1982-01-01)
Use of the CH lymphomas as models of murine B cell differentiation.
G A Bishop et al.
Immunologic research, 5(4), 263-270 (1986-01-01)
C A Pennell et al.
Proceedings of the National Academy of Sciences of the United States of America, 82(11), 3799-3803 (1985-06-01)
A series of 27 B-cell lymphomas (designated the CH series), induced in B10.H-2aH-4b p/Wts mice by intense adoptive immunization with sheep erythrocytes, was found to represent a subset of the total B-cell repertoire. This subset was characterized by expression of
The CH series of murine B cell lymphomas: neoplastic analogues of Ly-1+ normal B cells.
G Haughton et al.
Immunological reviews, 93, 35-51 (1986-10-01)
T J Mercolino et al.
The Journal of experimental medicine, 163(1), 155-165 (1986-01-01)
Cells from 6 of 14 different Ly-1+ murine B cell lymphomas bound to synthetic liposomes encapsulating fluorescein. The liposomes were made from distearoyl phosphatidyl choline (DSPC), distearoyl phosphatidyl glycerol (DSPG), and cholesterol. In all cases, liposome binding was due to
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