AG938

Synuclein, α, recombinant human

• Synonyme(s) : α-Synuclein protein, Alpha Synuclein
• Code UNSPSC : 12352200
• eCl@ss : 32160405
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: human
• Niveau de qualité: 100
• Pureté: >95% (gel scan and mass spectrometry)
• Forme: solid
• Durée de conservation: 12 mo.
• Fabricant/nom de marque: Chemicon^®
• Solubilité: water: slightly soluble
• Adéquation: suitable for molecular biology
• Numéro d'accès NCBI: NM_000345.2; NM_007308.1
• Numéro d'accès UniProt: P37840
• Informations sur le gène: human ... SNCA(6622)

Description

Description générale

Research area: Neuroscience

α-Synuclein, a member of the synuclein family of proteins that localize to presynaptic terminals under physiological conditions. It is comprised of three primary regions: an amino terminus containing apolipoprotein lipid-binding motifs, which are anticipated to form amphiphilic helices. The central region, known as non-Aβ component (NAC) containing a hydrophobic domain that gives β-sheet potential, and the carboxyl terminus, characterized by a high negative charge and remains unstructured. Under physiological conditions, members of the synuclein family, including α-synuclein, are predominantly neuronal proteins.

Application

Synuclein, α, recombinant human has been used:

• for preparation of α-synuclein fibrils to access the SAR228810 antibody against the risk of amyloid-related imaging abnormalities (ARIA).
• to study the formation of isoasparate protein damage responsible to trigger familial Parkionsonian phenotypes.
• to study its interaction with iron and copper, in order to understand their role in proteinopathies.

Actions biochimiques/physiologiques

Synuclein, α is the principal component of Lewy bodies and a pathological hallmark of synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). The deposition of αS aggregates is a defining characteristic of all these diseases.

Forme physique

Lyophilized from TBS. Resuspend in water at a concentration of 1 mg/mL.

Stockage et stabilité

Maintain lyophilized material at -20ºC for up to 12 months after date of receipt. After reconstitution maintain at -20ºC to -70ºC for up to 2 weeks in undiluted aliquots. Avoid freeze/thaw cycles to avoid aggregation.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable