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Key Documents

AB2204

Sigma-Aldrich

Anti-BMAL1 Antibody

serum, from guinea pig

Synonyme(s) :

ARNT-like protein 1, brain and muscle, Basic-helix-loop-helix-PAS protein MOP3, Brain and muscle ARNT-like 1, member of PAS protein 3, aryl hydrocarbon receptor nuclear translocator-like, bHLH-PAS protein JAP3, basic-helix-loop-helix-PAS orphan MOP3 2, m

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

guinea pig

Niveau de qualité

100

Forme d'anticorps

serum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Espèces réactives

mouse, human, rat

Technique(s)

western blot: suitable

Numéro d'accès NCBI

NP_031515

Numéro d'accès UniProt

O00327

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... ARNTL(406)
mouse ... Arntl(11865)
rat ... Arntl(29657)

Description générale

Brain and muscle Arnt-like protein-1 (BMAL1; also known as MOP3 or Arnt3) is a transcription factor known to regulate circadian rhythm. BMAL1 is the only component of the mammalian circadian clock whose sole deletion in a mouse model generates arrhythmicity. In addition to defects in the clock, these BMAL1 null-mice also have reproductive problems are small in stature, age quickly and have progressive arthropathy that results in having less overall locomotor activity than wild type mice. Recent phenotyping data suggests that BMAL1 and its partner Clock also play a role in regulation of glucose homeostasis and metabolism. Finally, BMAL1, NPAS2, and PER2 have been associated with seasonal affective disorder in humans. BMAL1 transcription is circadian and reciprocally regulated by NR1D1 (Rev-erb-alpha) and RORA, which establishes a second interlocking loop in the mammalian circadian clock.

Spécificité

Cat. # AB2204 will recognize the C-terminus of BMAL1.
Reactivity with other species has not been tested.

Immunogène

Epitope: C-Terminus
Recombinant Protein

Application

Anti-BMAL1 Antibody is an antibody against BMAL1 for use in WB.
Research Category
Neuroscience
Research Sub Category
Circadian Rhythm & Sleep

Qualité

Routinely tested on C2C12 tissue lysate
Lot Specific Tested Application 1: Western Blot

Description de la cible

~69 kDa

Forme physique

Serum with 0.05% NaN3

Stockage et stabilité

Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.

Remarque sur l'analyse

Control
C2C12 Tissue lysate

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Jeff R Jones et al.
Nature communications, 12(1), 5763-5763 (2021-10-03)
Signals from the central circadian pacemaker, the suprachiasmatic nucleus (SCN), must be decoded to generate daily rhythms in hormone release. Here, we hypothesized that the SCN entrains rhythms in the paraventricular nucleus (PVN) to time the daily release of corticosterone.
Karen J Tonsfeldt et al.
Journal of the Endocrine Society, 3(4), 716-733 (2019-03-25)
In rodents, the preovulatory LH surge is temporally gated, but the timing cue is unknown. Estrogen primes neurons in the anteroventral periventricular nucleus (AVPV) to secrete kisspeptin, which potently activates GnRH neurons to release GnRH, eliciting a surge of LH
Antibodies for assessing circadian clock proteins in the rodent suprachiasmatic nucleus.
LeSauter, J; Lambert, CM; Robotham, MR; Model, Z; Silver, R; Weaver, DR
Testing null
Eric L Bittman
Methods in molecular biology (Clifton, N.J.), 2482, 191-210 (2022-05-25)
The mammalian suprachiasmatic nucleus (SCN) functions as a master circadian pacemaker. In order to examine mechanisms by which it keeps time, entrains to periodic environmental signals (zeitgebers), and regulates subordinate oscillators elsewhere in the brain and in the periphery, a
Yohei Kobayashi et al.
Neuron, 86(1), 264-275 (2015-03-25)
Circadian rhythms control a variety of physiological processes, but whether they may also time brain development remains largely unknown. Here, we show that circadian clock genes control the onset of critical period plasticity in the neocortex. Within visual cortex of
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