8.52347

Fmoc-Tyr(SO3nP)-OH

≥95.0% (HPLC), for peptide synthesis, Novabiochem^®

• Synonyme(s) : Fmoc-Tyr(SO3nP)-OH, N-Fmoc-O-(2,2 dimethylpropylsulfo)-L-tyrosine
• Formule empirique (notation de Hill): C₂₉H₃₁NO₈S
• Numéro CAS: 878408-63-0
• Poids moléculaire : 553.62
• Code UNSPSC : 12352209
• Nomenclature NACRES : NA.22

Propriétés

• product name: Fmoc-Tyr(SO3nP)-OH, Novabiochem^®
• Niveau de qualité: 200
• Gamme de produits: Novabiochem^®
• Pureté: ≥95.0% (HPLC)
• Forme: powder
• Capacité de réaction: reaction type: Fmoc solid-phase peptide synthesis
• Fabricant/nom de marque: Novabiochem^®
• Application(s): peptide synthesis
• Groupe fonctionnel: sulfonic acid
• Température de stockage: -10 to -25°C

Description

Description générale

A novel derivative for the synthesis of sulfotyrosine-containing peptides by Fmoc SPPS. The sulfate neopentyl group is stable to TFA, and thus protects the sulfotyrosine residue from degradation during the cleavage reaction, but is easily cleaved post-cleavage by treatment of the peptide with aqueous ammonium acetate ^[1].

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Guide to Selection of Orthogonally -Protected Building Blocks for Fmoc SPPS

Literature references

^[1] L. S. Simpson & T. S. Widlanski (2006) J. Am. Chem. Soc., 128, 1605.
^[2] L. S. Simpson, et al. (2009) Chemistry & Biology, 16, 153.

Remarque sur l'analyse

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (DC(BAW0)): ≥ 97 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1 mmole in 4 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Informations légales

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable