8.51005

DSC

≥99.0% (HPLC), for peptide synthesis, Novabiochem^®

• Synonyme(s) : DSC, N,N′-Disuccinimidyl carbonate, Di-(N-Succinimidyl)carbonate
• Formule empirique (notation de Hill): C₉H₈N₂O₇
• Numéro CAS: 74124-79-1
• Poids moléculaire : 256.17
• Numéro MDL: MFCD00009767
• Code UNSPSC : 12352108
• Numéro de classement CE : 277-730-3
• Nomenclature NACRES : NA.22

Propriétés

• product name: DSC, N,N′-Disuccinimidyl carbonate Novabiochem^®
• Niveau de qualité: 200
• Gamme de produits: Novabiochem^®
• Pureté: ≥99.0% (HPLC)
• Forme: powder
• Capacité de réaction: reaction type: Coupling Reactions
• Fabricant/nom de marque: Novabiochem^®
• Pf: 188-191 °C
• Application(s): peptide synthesis
• Température de stockage: 2-8°C
• InChI: 1S/C9H8N2O7/c12-5-1-2-6(13)10(5)17-9(16)18-11-7(14)3-4-8(11)15/h1-4H2
• Clé InChI: PFYXSUNOLOJMDX-UHFFFAOYSA-N

Description

Description générale

A convenient reagent for the synthesis of N-succinimidyl esters of N-protected amino acids ^[1,2,3,4].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] H. Ogura, et al. (1979) Tetrahedron Lett., 20, 4745.
^[2] H. Ogura, et al. (1981) Tetrahedron Lett., 22, 4817.
^[3] K. Takeda, et al. (1982) Synth. Commun., 12, 213.
^[4] K. Takeda, et al. (1983) TetrahedronLett., 24, 4569.

Application

• Utilization in solid-phase peptide synthesis: Discusses the role of N,N′-disuccinimidyl carbonate in solid-phase peptide synthesis, providing insights into its effectiveness in enhancing coupling reactions (Meschaninova et al., 2019).
• Surface functionalization of polymeric materials: This article explores the application of N,N′-disuccinimidyl carbonate in the surface functionalization of polymers to improve their biocompatibility and interaction with biological molecules (Yakufu et al., 2020).
• Development of affinity chromatography technologies: Details the use of N,N′-disuccinimidyl carbonate in the development of novel affinity chromatography approaches for protein purification (Hinamoto et al., 2023).
• Enhancement of polymer properties: Investigates how N,N′-disuccinimidyl carbonate can be used to modify polymer surfaces to enhance their properties, such as increased hydrophilicity and reactivity (Swar et al., 2020).

Liaison

Replaces: 01-62-0006

Remarque sur l'analyse

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Water (K. F.): ≤ 0.50 %
Identity (IR): passes test

Informations légales

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS07,GHS08
• Mention d'avertissement: Warning
• Mentions de danger: H302 - H319 - H373
• Conseils de prudence: P260 - P264 - P270 - P301 + P312 - P305 + P351 + P338 - P314
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2 - STOT RE 2 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable