8.18737

Chlorotrimethylsilane

for synthesis

• Synonyme(s) : Chlorotrimethylsilane, Trimethylchlorosilane, Trimethylsilyl chloride, TMCS
• Formule linéaire : (CH₃)₃SiCl
• Numéro CAS: 75-77-4
• Poids moléculaire : 108.64
• Numéro MDL: MFCD00000502
• Code UNSPSC : 12352103
• Numéro de classement CE : 200-900-5
• Nomenclature NACRES : NA.22

Propriétés

• Pression de vapeur: 250 hPa ( 20 °C)
• Niveau de qualité: 200
• Pureté: ≥99.0% (GC)
• Forme: liquid
• Température d'inflammation spontanée: 420 °C
• Puissance: 4868 mg/kg LD₅₀, oral (Rat); 1530 mg/kg LD₅₀, skin (Rabbit)
• Limite d'explosivité: 1.5-46 % (v/v)
• Point d'ébullition: 57 °C/1013 hPa
• Pf: -58 °C
• Température de transition: flash point -20 °C
• Densité: 0.86 g/cm³ at 20 °C
• Température de stockage: 2-30°C
• InChI: 1S/C3H9ClSi/c1-5(2,3)4/h1-3H3
• Clé InChI: IJOOHPMOJXWVHK-UHFFFAOYSA-N

Description

Application

• Synthesis of bis ferrocene derivatives: Development of new ferrocenyl multi-functional silyl ether compounds using chlorotrimethylsilane, highlighting advances in organosilicon chemistry (R Teimuri-Mofrad et al., 2016).
• Pharmacologically active derivatives: Use of chlorotrimethylsilane as a catalyst in the synthesis of pharmacologically active bis (indolyl) and tris (indolyl) derivatives, demonstrating its efficiency in electrophilic substitution reactions (NG Singh et al., 2014).
• Silicone resin synthesis: Exploration of the hydrolysis-condensation reaction of tetraethoxysilane and chlorotrimethylsilane to create silicone resins, showing the material′s enhanced properties for industrial applications (CFJ Kuo et al., 2014).
• Deoxygenation of unsymmetrical dicarbonyl compounds: Innovative use of chlorotrimethylsilane and sodium iodide for the selective reduction of 1,2-diketones, showcasing a novel method in organic synthesis (LZ Yuan et al., 2016).
• Enhanced activity and durability of catalysts: Investigation into Fe3+ and chlorotrimethylsilane modified NaY catalysts for the acetalization of glycerol to solketal, improving catalytic performance in chemical processes (Y Li et al., 2023).

Remarque sur l'analyse

Assay (GC, area%): ≥ 99.0 % (a/a)
Density (d 20 °C/ 4 °C): 0.858 - 0.861
Identity (IR): passes test

Informations sur la sécurité

• Pictogrammes: GHS02,GHS05,GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H225 - H301 + H331 - H312 - H314
• Conseils de prudence: P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classification des risques: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A
• Risques supp: EUH014
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): -18.4 °F - closed cup
• Point d'éclair (°C): -28 °C - closed cup