8.00907

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

for peptide synthesis

• Synonyme(s) : N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride
• Formule empirique (notation de Hill): C₈H₁₇N₃ · xHCl
• Numéro CAS: 25952-53-8
• Poids moléculaire : 155.24 (free base basis)
• Numéro MDL: MFCD00012503
• Code UNSPSC : 12352107
• Numéro de classement CE : 247-361-2
• Nomenclature NACRES : NA.22

Propriétés

• product name: N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride, for synthesis
• Niveau de qualité: 200
• Forme: solid
• Capacité de réaction: reaction type: Coupling Reactions
• Pf: 110-115 °C
• Application(s): peptide synthesis
• Température de stockage: −20°C (−15°C to −25°C)
• InChI: 1S/C8H17N3.ClH/c1-4-11(8-9)7-5-6-10(2)3;/h4-7H2,1-3H3;1H
• Clé InChI: FDXPUDRRFDHONO-UHFFFAOYSA-N

Description

Description générale

N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride, also known as EDAC HCl or WSC, is a water-soluble condensing reagent. EDAC HCl is generally used to couple carboxylic acids with amines to form amides. The by-product urea is water-soluble and can be removed from immiscible reaction milieux by extraction with water. It is principally utilized in solution-phase peptide synthesis and as a zero-length crosslinker for protein modification.

Application

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC hydrochloride) can be used as:

• A water-soluble carbodiimide to facilitate peptide coupling reactions in alcohols.
• A coupling agent along with HOBt to synthesize poly(glutamic acid) (PGA) polypeptides for the creation of non-fouling polypeptides that could be useful in a variety of biomedical applications.
• A coupling reagent for the efficient synthesis of teriflunomide at the industrial scale.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H302 - H311 - H315 - H317 - H373 - H410
• Conseils de prudence: P260 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P314
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral
• Code de la classe de stockage: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable